Author

Juliet W. Lefferts

Utrecht UniversityORCID 0000-0002-7786-8575Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:clustering· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:imaging· 1 Approach:variational autoencoder· 1

Frequent Co-Authors

Enrico MastrobattistaiD· 2 shared Anne F. J. JansseniD· 1 shared Annet C. W. van Wesel· 1 shared Antonio Garcia-GuerraiD· 1 shared Bram M. BoschiD· 1 shared Caspar T. H. JonkeriD· 1 shared Charlotte V. HegemaniD· 1 shared Cornelis A. T. van den BergiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBioinformatics

Enrico MastrobattistaORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

UDIST: unsupervised disentanglement of shape and texture for multi-scale phenotypic profiling in 2D microscopy

Bram M. Bosch, Maarten L. Terpstra, Matthew B. Smith, Krijn H. van der Steen, Caspar T. H. Jonker, Vitalijs Ovcinnikovs, Thomas H. Wesselink, Anne F. J. Janssen, Lianne Winkel, Eva M.A. Huigen, Juliet W. Lefferts, Enrico Mastrobattista, Edo Elstak, Cornelis A. T. van den Berg, Jeffrey Matthijn Beekman, Sam F.B. van Beuningen

UDIST separates shape and texture in microscopy images into independent latent subspaces, enabling unbiased phenotypic analysis across biological scales.

bioRxiv · Jul 29, 2026 · PreprintBioinformatics

A modular strategy for extracellular vesicle-mediated CRISPR-Cas9 delivery through aptamer-based loading and UV-activated cargo release

Omnia M. Elsharkasy, Charlotte V. Hegeman, Tom A. P. Driedonks, Xiuming Liang, Ivana Lansweers, Olaf L. Cotugno, Ingmar Y. de Groot, Zoë E. M. N. J. de Wit, Antonio Garcia-Guerra, Niels J. A. Moorman, Sjoerd H. Boonstra, Esmeralda Bosman, Juliet W. Lefferts, Willemijn S. de Voogt, Jerney J. Gitz-Francois, , Olivier G. de Jong

This paper develops a modular strategy for delivering CRISPR-Cas9 via extracellular vesicles using aptamer-based loading and UV-activated cargo release, demonstrating efficient delivery and versatility in Cas9 variants.

Nature Communications · Nov 21, 2025Peer-reviewedMolecular Biology