Author

J. A. Goldsmith

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 3 Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein structure prediction· 1 Approach:simulation· 1 Organism:virus· 1

Frequent Co-Authors

J. S. McLellan· 3 shared C.-L. Hsieh· 2 shared D. Wrapp· 2 shared N. Wang· 2 shared A. Dzifa· 1 shared A. G.-W. Lee· 1 shared A. M. DiVenere· 1 shared A. Ourmazd· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersMicrobiology

J. S. McLellan

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Author profile →

3 papers

Recent·Most cited

A glycan gate controls opening of the SARS-CoV-2 spike protein

T. E. Sztain, S.-H. Ahn, A. T. Bogetti, L. Casalino, J. A. Goldsmith, E. Seitz, R. S. McCool, F. L. Kearns, F. Acosta-Reyes, S. Maji, G. Mashayekhi, J. A. McCammon, A. Ourmazd, J. Frank, J. S. McLellan, , R. E. Amaro

This study identifies a glycan gate and key residues that facilitate SARS-CoV-2 spike protein RBD opening through simulations and experimental validation.

bioRxiv · Feb 15, 2021Biophysics

Structure-based Design of Prefusion-stabilized SARS-CoV-2 Spikes

C.-L. Hsieh, J. A. Goldsmith, J. M. Schaub, A. M. DiVenere, H.-C. Kuo, K. Javanmardi, K. C. Le, D. Wrapp, A. G.-W. Lee, Y. Liu, C.-W. Chou, P. O. Byrne, C. K. Hjorth, N. V. Johnson, J. Ludes-Meyers, , J. S. McLellan

This study designs and characterizes prefusion-stabilized SARS-CoV-2 spike variants to improve protein yield and stability for vaccine and diagnostic development.

bioRxiv · May 30, 2020Microbiology

Cryo-EM Structure of the 2019-nCoV Spike in the Prefusion Conformation

D. Wrapp, N. Wang, K. S. Corbett, J. A. Goldsmith, C.-L. Hsieh, O. Abiona, B. S. Graham, J. S. McLellan

The paper determines the cryo-EM structure of the 2019-nCoV Spike protein in the prefusion conformation and shows higher ACE2 binding affinity compared to SARS-CoV.

Science · Mar 13, 2020Peer-reviewedMicrobiology