Author

F. L. Kearns

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:virus· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:simulation· 2 Assay:structural biology· 2 Assay:cryo-EM· 1 Approach:deep learning· 1

Frequent Co-Authors

R. E. Amaro· 5 shared M. A. Rosenfeld· 4 shared L. Casalino· 3 shared J. S. McLellan· 2 shared S.-H. Ahn· 2 shared A. D. Davidson· 1 shared A. D. Steigmeyer· 1 shared A. J. Mulholland· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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5 shared papersBiophysics

R. E. Amaro

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Allosteric modulation by the fatty acid site in the glycosylated SARS-CoV-2 spike

A. S. F. Oliveira, F. L. Kearns, M. A. Rosenfeld, L. F. Casalino, L. Tulli, I. Berger, C. Schaffitzel, A. D. Davidson, R. E. Amaro, A. J. Mulholland

This paper uses D-NEMD simulations to study how the fatty acid site in the glycosylated SARS-CoV-2 spike modulates its structure and function, revealing allosteric networks and the role of glycans.

bioRxiv · Nov 6, 2023Biochemistry

Simulation-Driven Design of Stabilized SARS-CoV-2 Spike S2 Immunogens

X. Nuqui, L. Casalino, L. Zhou, M. Shehata, A. Wang, A. L. Tse, A. Ojha, F. L. Kearns, M. A. Rosenfeld, E. H. Miller, C. M. Acreman, S.-H. Ahn, K. Chandran, J. S. McLellan, R. E. Amaro

This study designs stabilized SARS-CoV-2 S2 immunogens using simulation-driven approaches, showing improved stability and immunogenicity.

bioRxiv · Oct 24, 2023Biophysics

Glycoproteomic landscape and structural dynamics of TIM family immune checkpoints enabled by mucinase SmE

J. Chongsaritsinsuk, A. D. Steigmeyer, K. E. Mahoney, M. A. Rosenfeld, T. M. Lucas, D. Ince, F. L. Kearns, A. S. Battison, M. A. Hollenhorst, J. Shon, K. H. Tiemeyer, V. Attah, C. Kwon, C. R. Bertozzi, M. J. Ferracane, , S. A. Malaker

The paper uses a mucinase to analyze glycoproteomic features of TIM family proteins and shows how glycosylation affects their structure through molecular dynamics simulations.

bioRxiv · Feb 1, 2023Cancer Biology

Targeted protein S-nitrosylation of ACE2 as potential treatment to prevent spread of SARS-CoV-2 infection

C.-k. Oh, T. Nakamura, N. Beutler, X. Zhang, J. Pina-Crespo, M. Talantova, S. Ghatak, D. Trudler, L. N. Carnevale, S. R. McKercher, M. A. Bakowski, J. K. Diedrich, A. J. Roberts, A. K. Woods, V. Chi, , S. A. Lipton

This paper develops aminoadamantane nitrate compounds that inhibit SARS-CoV-2 infection by S-nitrosylating ACE2 and blocking viral entry, showing efficacy in vitro and in a Syrian hamster model.

bioRxiv · Apr 5, 2022Microbiology

A glycan gate controls opening of the SARS-CoV-2 spike protein

T. E. Sztain, S.-H. Ahn, A. T. Bogetti, L. Casalino, J. A. Goldsmith, E. Seitz, R. S. McCool, F. L. Kearns, F. Acosta-Reyes, S. Maji, G. Mashayekhi, J. A. McCammon, A. Ourmazd, J. Frank, J. S. McLellan, , R. E. Amaro

This study identifies a glycan gate and key residues that facilitate SARS-CoV-2 spike protein RBD opening through simulations and experimental validation.

bioRxiv · Feb 15, 2021Biophysics