Author

J. A. Larouche

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Organism:mouse· 4 Assay:ATAC-seq· 2 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:development & morphogenesis· 2

Frequent Co-Authors

C. A. Aguilar· 5 shared B. A. Yang· 4 shared P. M. Fraczek· 3 shared B. D. Spence· 2 shared C. Davis· 2 shared E. C. Wallace· 2 shared S. V. Brooks· 2 shared A. Eames· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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5 shared papersCell Biology

C. A. Aguilar

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Author profile →

5 papers

Recent·Most cited

Manipulation of the nucleoscaffold potentiates cellular reprogramming kinetics

B. A. Yang, A. Monteiro da Rocha, I. Newton, A. Shcherbina, S.-W. Wong, P. M. Fraczek, J. A. Larouche, H. L. Hiraki, B. M. Baker, J.-W. Shin, S. Takayama, M. D. Thouless, C. A. Aguilar

This study shows that manipulating Lamin A/C affects nuclear structure and reprogramming efficiency in human fibroblasts.

bioRxiv · Mar 12, 2023Cell Biology

Maresin 1 Repletion Improves Muscle Regeneration After Volumetric Muscle Loss

J. A. Castor-Macias, J. A. Larouche, E. C. Wallace, B. D. Spence, A. Eames, B. A. Yang, C. Davis, S. V. Brooks, K. R. Maddipati, J. F. Markworth, C. A. Aguilar

This study shows that Maresin 1 treatment reduces fibrosis and improves muscle regeneration after volumetric muscle loss by modulating inflammation.

bioRxiv · Nov 19, 2022Physiology

Three-dimensional chromatin re-organization during muscle stem cell aging

B. A. Yang, J. A. Larouche, K. M. Sabin, P. M. Fraczek, S. C. J. Parker, C. A. Aguilar

This study examines how 3D chromatin organization changes in muscle stem cells during aging, revealing static global structures and rewired local contacts linked to transcription factor binding and gene expression changes.

bioRxiv · Sep 21, 2022Cell Biology

Spatiotemporal mapping of immune and stem cell dysregulation after volumetric muscle loss

J. A. Larouche, E. C. Wallace, B. D. Spence, S. A. Johnson, M. Kulkarni, E. Buras, B. N. Brown, S. F. Badylak, C. A. Aguilar

This study identifies a pro-fibrotic immune-progenitor cell interaction in VML that impairs muscle regeneration, showing conservation across mouse and canine models.

bioRxiv · Jun 3, 2022Cell Biology

Neutrophil and natural killer cell imbalances prevent muscle stem cell mediated regeneration following murine volumetric muscle loss

J. A. Larouche, S. J. Kurpiers, B. A. Yang, C. Davis, P. M. Fraczek, M. Hall, S. V. Brooks, L. D. Shea, C. A. Aguilar

The study compares muscle injuries leading to regeneration or fibrosis, revealing that neutrophil-natural killer cell communication affects muscle stem cell repair.

bioRxiv · Jul 2, 2021Cell Biology