J. F. Markworth

Maresin 1 Repletion Improves Muscle Regeneration After Volumetric Muscle Loss

This study shows that Maresin 1 treatment reduces fibrosis and improves muscle regeneration after volumetric muscle loss by modulating inflammation.

Local Shifts in Inflammatory and Resolving Lipid Mediators in Response to Tendon Overuse

This study identifies delayed and prolonged inflammatory responses in overused tendons, marked by elevated pro-inflammatory eicosanoids and reduced pro-resolving lipid mediators.

Lipidomic Profiling Reveals an Age-Related Deficiency of Skeletal Muscle Proresolving Mediators that Contributes to Maladaptive Tissue Remodeling

This study identifies age-related deficiencies in proresolving mediators in skeletal muscle, leading to impaired regeneration and inflammation, and shows that RvD1 treatment can mitigate some adverse effects.

Immunoresolvents Support Skeletal Myofiber Regeneration via Actions on Myeloid and Muscle Stem Cells

This study shows that resolvin D1 promotes skeletal muscle regeneration by modulating myeloid cells and muscle stem cells, improving recovery without directly affecting myogenesis.

Single Cell Deconstruction of Muscle Stem Cell Heterogeneity During Aging Reveals Sensitivity to the Neuromuscular Junction

The paper identifies a neuro-responsive subset of muscle stem cells that support neuromuscular junction integrity during aging and neurodegeneration.

Postnatal Tendon Growth and Remodeling Requires Platelet-Derived Growth Factor Receptor Signaling

This study shows PDGFR signaling is essential for postnatal tendon growth and remodeling, with MT1-MMP mediating fibroblast migration and being regulated by PI3K/Akt and ERK1/2.