Author

J.-W. Shin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Cell Biology· 2 Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 5 Research Focus:cell type annotation· 4 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Assay:ATAC-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

D. Mehta· 2 shared D.-Y. Yoon· 2 shared J. Lee· 2 shared Y. Bak· 2 shared A. Monteiro da Rocha· 1 shared A. Rivera· 1 shared A. Shcherbina· 1 shared B. A. Yang· 1 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersBioengineering

D. Mehta

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Matrimeres are systemic nanoscale mediators of tissue integrity and function

K. Debnath, I. Qayoom, S. O'Donnell, J. Ekiert, C. Wang, M. A. Sanborn, C. Liu, A. Rivera, I. S. Cho, S. Saichellappa, P. T. Toth, D. Mehta, J. Rehman, X. Du, Y. Gao, J.-W. Shin

The paper identifies matrimeres as nanoscale mediators of tissue integrity, showing they can restore vascular integrity after injury and are reconstituted from fibronectin, DNA, and acidic conditions.

bioRxiv · Mar 25, 2024 · PreprintBioengineering

Tension sensing by FAK governs nuclear mechanotransduction, endothelial transcriptome and fate

M. Z. Akhter, P. Yazbeck, M. Tauseef, M. Anwar, F. Hossen, S. Datta, V. Vellingiri, J. C. Joshi, N. Srivastava, S. Lenzini, G. Zhou, J. Lee, M. K. Jain, J.-W. Shin, D. Mehta

This study shows that FAK-mediated tension sensing in endothelial cells regulates nuclear mechanotransduction, transcriptome, and cell fate, crucial for maintaining a restrictive endothelial barrier.

bioRxiv · Apr 24, 2023 · PreprintCell Biology

Manipulation of the nucleoscaffold potentiates cellular reprogramming kinetics

B. A. Yang, A. Monteiro da Rocha, I. Newton, A. Shcherbina, S.-W. Wong, P. M. Fraczek, J. A. Larouche, H. L. Hiraki, B. M. Baker, J.-W. Shin, S. Takayama, M. D. Thouless, C. A. Aguilar

This study shows that manipulating Lamin A/C affects nuclear structure and reprogramming efficiency in human fibroblasts.

bioRxiv · Mar 12, 2023Cell Biology

Material-mediated histogenesis using mechano-chemically microstructured cell niches

P. L. H. Newman, Q. Yip, P. Osteil, T. A. Anderson, J. Q. J. Sun, D. Kempe, M. Biro, J.-W. Shin, P. P. L. Tam, H. Zreiqat

The paper develops a method to create microstructured cell niches that guide tissue formation by mediating mechano-chemical signals, improving reproducibility and physiological accuracy of stem-cell-derived tissues.

bioRxiv · Feb 10, 2021Bioengineering

Calotropis gigantea extract induces apoptosis through extrinsic/intrinsic pathways and upregulation of reactive oxygen species in non-small-cell lung cancer cells

D.-Y. Yoon, J. Lee, H. Jang, Y. Bak, J.-W. Shin, H. Jin, Y.-I. Kim, H. W. Ryu, R. Oh

This study shows that Calotropis gigantea extract induces apoptosis in NSCLC cells via extrinsic and intrinsic pathways and ROS generation.

bioRxiv · Oct 11, 2018Cancer Biology

(E)-2-Benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one (BCI) Induces Apoptosis Via The Intrinsic Pathway In H1299 Lung Cancer Cells

J.-W. Shin, S.-B. Kwon, Y. Bak, S. Lee, D.-Y. Yoon

This study shows that BCI induces apoptosis in NCI-H1299 lung cancer cells via the intrinsic pathway by increasing Bax, caspase-9/3, and cytochrome c release while decreasing Bcl-2.

bioRxiv · Apr 26, 2017Pharmacology & Toxicology