M. Hall

Wetland tree barks are dynamic hotspots for microbial trace gas cycling

The paper identifies microbial communities in wetland tree barks that mediate methane and hydrogen cycling, showing they can both mitigate and emit climate-active gases.

Cryo-EM insight into hydrogen positions and water networks in photosystem II

Cryo-EM structure of PSII at 1.71 [A] resolution reveals over 50% of hydrogen and proton sites and additional water binding sites, aiding catalytic insight.

Branched-chain keto acids promote an immune-suppressive and neurodegenerative microenvironment in leptomeningeal disease

This study identifies branched-chain keto acid accumulation in leptomeningeal disease CSF, showing immune suppression and neurodegeneration, and shows that reducing BCKA improves outcomes in mouse models.

Diet-induced changes in metabolism influence immune response and viral shedding dynamics in Jamaican fruit bats

The study shows diet affects viral shedding in Jamaican fruit bats, with suboptimal-sugar diets leading to higher viral RNA shedding than suboptimal-fat diets.

A scenario-guided strategy for the future management of biological invasions

The paper develops a scenario-based strategy for managing invasive alien species in Europe, identifying key recommendations and assessing their feasibility across different future scenarios.

A search for "perio-probiotics" by longitudinal dissection of oral bacterial community shifts during the onset and resolution of gingivitis

This study tracks oral bacterial changes during gingivitis onset and resolution, identifying potential probiotic taxa and highlighting plaque as a key site for diagnostic testing.

Tumor-educated monocytes suppress T cells via adenosine and depletion of adenosine in the tumor microenvironment with adenosine deaminase enzyme promotes response to immunotherapy

This study shows that tumor-educated monocytes suppress T cells via adenosine and that depleting adenosine with PEG-ADA enhances immunotherapy response in preclinical models.

Target Class Profiling of Small Molecule Methyltransferases

The paper develops a target class profiling approach to study small molecule methyltransferases, identifies a novel HNMT inhibitor, and demonstrates its utility for drug discovery.

Asymmetric Structure of the Native Rhodobacter sphaeroides Dimeric LH1-RC Complex

This paper presents cryo-EM structures of the dimeric LH1-RC complex from Rhodobacter sphaeroides, revealing asymmetric features and the role of protein-U in complex assembly.

Neutrophil and natural killer cell imbalances prevent muscle stem cell mediated regeneration following murine volumetric muscle loss

The study compares muscle injuries leading to regeneration or fibrosis, revealing that neutrophil-natural killer cell communication affects muscle stem cell repair.

A Novel Membrane Protein in the Rhodobacter sphaeroides LH1-RC Photocomplex

The paper presents a cryo-EM structure of the LH1-RC complex from Rhodobacter sphaeroides, identifying a new membrane protein and revealing structural insights into its dimerization and function.

A hybrid in silico approach reveals novel inhibitors of multiple SARS-CoV-2 variants

The paper uses a hybrid in silico approach combining machine learning and pharmacophore modeling on NCATS screening data to identify novel inhibitors effective against multiple SARS-CoV-2 variants.

Cryo-EM Structure of the Photosynthetic LH1-RC Complex from Rhodospirillum rubrum

The paper presents a cryo-EM structure of the LH1-RC complex from Rhodospirillum rubrum, revealing its architecture, pigment organization, and protein interactions.

High-resolution model of Arabidopsis Photosystem II reveals the structural consequences of digitonin-extraction

The paper presents a high-resolution Cryo-EM structure of Arabidopsis PSII and identifies structural features and detergent effects on its stability.

Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2

The paper identifies 319 compounds with anti-SARS-CoV-2 activities through a high-throughput screen, including 91 approved drugs and 49 investigational drugs, with 230 compounds previously unreported.

Massive-scale biological activity-based modeling identifies novel antiviral leads against SARS-CoV-2

This paper develops a biological activity-based modeling approach to identify novel antiviral compounds against SARS-CoV-2 with high hit rates in live virus assays.

Discovery of Synergistic and Antagonistic Drug Combinations against SARS-CoV-2 In Vitro

This study identifies synergistic and antagonistic drug combinations against SARS-CoV-2 in vitro using in silico prioritization and experimental testing.

Alternative polyadenylation is a determinant of oncogenic Ras function

This study shows that alternative polyadenylation regulates oncogenic Ras function by affecting transcript 3' UTR length in both C. elegans and human cells.

Amino acid quality modifies the quantitative availability of protein for reproduction in Drosophila melanogaster

This study shows that amino acid quality affects protein availability for reproduction in Drosophila melanogaster, altering how protein quantity impacts reproductive output across different diets.

Freshwater monitoring by nanopore sequencing

This paper presents a cost-effective nanopore sequencing workflow for freshwater monitoring, showing it can track microbiomes and detect pathogens with species-level resolution.

Genomic signatures of evolutionary rescue in bats surviving white-nose syndrome

The paper identifies genomic signatures of evolutionary rescue in bats surviving white-nose syndrome by analyzing genetic changes before and after population decline.

Bee visitation and fruit quality in berries under protected cropping vary along the length of polytunnels

The paper examines how bee visitation and fruit quality in berries vary along the length of polytunnels, finding higher pollinator activity and better fruit quality at tunnel ends.

Transmission trees on a known pathogen phylogeny: enumeration and sampling

The paper calculates the number of possible transmission trees from a phylogeny and provides a method to uniformly sample them, with an R package for implementation.

Pollinator size and its consequences: Predictive allometry for pollinating insects

This study develops predictive allometric models for pollinator body size using Bayesian and OLS regression, showing better interspecific than intraspecific predictions.

Host sexual dimorphism affects the outcome of within-host pathogen competition

The paper investigates how host sex influences pathogen competition in co-infections, finding that female hosts favor more virulent pathogens while male hosts show neutral or less virulent outcomes.

PHYLOSCANNER: Inferring Transmission from Within- and Between-Host Pathogen Genetic Diversity

PHYLOSCANNER infers transmission direction and identifies multiply infected individuals from pathogen genetic diversity across hosts using sequence data.

Copy-number signatures and mutational processes in ovarian carcinoma

This study identifies copy-number signatures in ovarian cancer and links them to mutational processes, showing that most cases involve multiple processes, suggesting therapeutic challenges.