Author

A. Durmaz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Evolutionary Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 7 Assay:bulk RNA-seq· 4 Research Focus:cell type annotation· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2

Frequent Co-Authors

J. G. Scott· 6 shared A. Dhawan· 2 shared A. M. Baschnagel· 2 shared A. Marusyk· 2 shared E. McClure· 2 shared J. Maltas· 2 shared J. Scott· 2 shared L. Abel· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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6 shared papersEvolutionary Biology

J. G. Scott

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Author profile →

8 papers

Recent·Most cited

Evolution under vancomycin selection drives divergent collateral sensitivity patterns in Staphylococcus aureus

K. J. Card, D. Crozier, A. Durmaz, J. M. Gray, J. Creary, A. Stocks, J. A. Maltas, R. A. Bonomo, Z. D. C. Burke, J. G. Scott

This study evolves Staphylococcus aureus under vancomycin selection, revealing two distinct adaptive pathways that lead to divergent collateral sensitivity patterns to first-line antibiotics.

bioRxiv · Nov 30, 2023Evolutionary Biology

Frequency-dependent ecological interactions increase the prevalence and shape the distribution of pre-existing drug resistance

J. Maltas, D. S. Tadele, A. Durmaz, C. D. McFarland, M. Hinczewski, J. G. Scott

This study shows frequency-dependent ecological interactions help pre-existing drug resistance persist despite fitness costs, using simulations and engineered mutants in NSCLC.

bioRxiv · Mar 16, 2023 · PreprintEvolutionary Biology

Leveraging the p53 signaling pathway as a radio-sensitization strategy in endometrial cancer

R. Vargas, A. Petty, A. Durmaz, K. Lin-Rahardja, O. Reizes, R. Debernardo, J. Scott

This study investigates how p53 signaling alterations affect radiotherapy response in endometrial cancer and explores p53 as a radio-sensitization strategy.

bioRxiv · Sep 6, 2022 · PreprintCancer Biology

Measuring competitive exclusion in non-small cell lung cancer

N. Farrokhian, J. Maltas, M. Dinh, A. Durmaz, P. Ellsworth, M. Hitomi, E. McClure, A. Marusyk, A. Kaznatcheev, J. G. Scott

This study measures frequency-dependent interactions between gefitinib-resistant and sensitive NSCLC populations to show that competitive exclusion depends on growth rate data, not just cost of resistance.

bioRxiv · Sep 18, 2020Cancer Biology

Development and Characterization of Patient-Derived Xenografts from Non-Small Cell Lung Cancer Brain Metastases

A. M. Baschnagel, S. Kaushik, A. Durmaz, S. Goldstein, I. M. Ong, L. Abel, P. A. Clark, T. Leal, D. Buehler, G. Iyer, J. G. Scott, R. J. Kimple

This study establishes and characterizes patient-derived xenografts of NSCLC brain metastases, showing strong phenotypic and molecular correlation with original tumors and therapeutic response to targeted treatments.

bioRxiv · Jun 2, 2020Cancer Biology

Identifying states of collateral sensitivity during the evolution of therapeutic resistance in Ewings sarcoma

J. A. Scarborough, E. McClure, P. Anderson, A. Dhawan, A. Durmaz, S. L. Lessnick, M. Hitomi, J. G. Scott

This study maps the temporal evolution of collateral sensitivity and resistance in Ewings sarcoma, showing unpredictable patterns in drug response and highlighting transcriptomic changes associated with these states.

bioRxiv · Feb 11, 2020Evolutionary Biology

Impact of immediate cryopreservation on the establishment of patient derived xenografts from head and neck cancer patients.

L. Abel, A. Durmaz, R. Hu, C. Longhurst, A. M. Baschnagel, D. L. Wheeler, J. G. Scott, R. J. Kimple

This study shows that fresh human cancer tissue can be cryopreserved and later implanted to establish PDXs without affecting growth rates or histologic parameters, enabling molecular profiling before implantation.

bioRxiv · Feb 3, 2020Cancer Biology

Resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressures

R. Vander Velde, N. Yoon, V. Marusyk, A. Durmaz, A. Dhawan, D. Myroshnychenko, D. Peral, B. Desai, O. Balynska, J. Poleszhuk, K. Liu, M. Abazeed, A. C. Tan, O. Mian, E. Haura, , A. Marusyk

The paper investigates resistance to ALK inhibitors in NSCLC, finding that resistance develops through gradual, multifactorial genetic and epigenetic changes rather than single mutations or reprogramming.

bioRxiv · Nov 19, 2019Cancer Biology