M. Topf

Modeling flexible protein structure with AlphaFold2 and cross-linking mass spectrometry

The paper introduces a pipeline combining AlphaFold2 and XL-MS to model protein conformations, showing improved accuracy in identifying correct structures using new scores.

Assessment of three-dimensional RNA structure prediction in CASP15

This paper evaluates RNA 3D structure prediction methods in CASP15, finding that non-deep learning groups outperformed deep learning models, with challenges in fine details and model ranking.

Cryo-EM structure and B-factorrefinement with ensemble representation

The paper introduces TEMPy-REFF, a method for refining atomic structures in cryo-EM maps using ensemble representations, showing improved fit compared to existing methods.

Gut Microbiota-Targeted Diets Modulate Human Immune Status

This study examines how plant-based fiber and fermented food diets affect the gut microbiome and immune system in healthy adults over 17 weeks.

The pore conformation of lymphocyte perforin

This study presents a high-resolution cryo-EM structure of the perforin pore, revealing conformational changes and interactions that explain its function and pathogenic mutations.

Molecular mechanism of a parasite kinesin motor and implications for its inhibition

This study characterizes the molecular mechanism of Plasmodium falciparum kinesin-5 (PfK5) and identifies structural features that could enable selective inhibition of this parasite's motor.

TopoStats - a program for automated tracing of biomolecules from AFM images

TopoStats automatically traces biomolecules in AFM images with high accuracy, identifying 90% of molecules and assemblies without prior processing.

CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers

This study uses cryo-EM to show how the complement membrane attack complex interacts with lipid bilayers through distinct mechanisms involving C6/C7 and C8/C9, revealing structural insights into pore formation and membrane disruption.