Author

J. B. Harris

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 7 Approach:experimental assay· 5 Assay:metagenomics· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:chromatin & epigenetic regulation· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

F. Qadri· 9 shared A. A. Weil· 8 shared A. I. Khan· 7 shared E. T. Ryan· 7 shared F. Chowdhury· 7 shared R. C. LaRocque· 7 shared S. B. Calderwood· 6 shared B. J. Shapiro· 4 shared

Activity by Year

2017-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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9 shared papersMicrobiology

F. Qadri

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Diversity of Vibrio cholerae O1 through the human gastrointestinal tract during cholera

P. Lypaczewski, D. Chac, C. N. Dunmire, K. M. Tandoc, F. Chowdhury, A. I. Khan, T. Bhuiyan, J. B. Harris, R. C. LaRocque, S. B. Calderwood, E. T. Ryan, F. Qadri, B. J. Shapiro, A. A. Weil

This study compares genetic diversity of Vibrio cholerae O1 in vomit and stool from cholera patients, finding reduced diversity in stool and some gene loss between samples.

bioRxiv · Feb 8, 2024Microbiology

Reemergence of cholera in Haiti

D. H. Rubin, F. G. Zingl, D. R. Leitner, R. Ternier, V. Compere, S. Marseille, D. M. Slater, J. B. Harris, F. Chowdhury, F. Qadri, J. Boncy, L. C. Ivers, M. K. Waldor

The paper investigates the origins of a new cholera outbreak in Haiti in 2022 using genomic and phenotypic analysis of Vibrio cholerae isolates.

bioRxiv · Oct 31, 2022Microbiology

Gut bacteria-derived sphingolipids alter innate immune responses to oral cholera vaccine antigens

D. Chac, F. J. Heller, H. A. Banna, M. H. Kaisar, F. Chowdhury, T. R. Bhuiyan, A. Akter, A. I. Khan, M. G. Dumayas, S. M. Markiewicz, A. Rice, P. C. Karmakar, P. Dash, R. C. LaRocque, E. T. Ryan, , A. A. Weil

This study links gut bacteria-derived sphingolipids to enhanced innate immune responses to an oral cholera vaccine using metagenomic and experimental approaches.

bioRxiv · Dec 1, 2021Microbiology

A combination of metagenomic and cultivation approaches reveals hypermutator phenotypes within Vibrio cholerae infected patients

I. Levade, A. I. Khan, F. Chowdhury, S. B. Calderwood, E. T. Ryan, J. B. Harris, R. C. LaRocque, T. R. Bhuiyan, F. Qadri, A. A. Weil, B. J. Shapiro

The paper combines metagenomics and cultivation approaches to show V. cholerae hypermutator phenotypes in infected patients, with evidence of adaptive mutations and transversion mutations.

mSystems · Aug 31, 2021Peer-reviewedMicrobiology

Impact of a human gut microbe on Vibrio cholerae host colonization through biofilm enhancement

K. Barrasso, D. Chac, M. D. Debele, C. Geigel, J. B. Harris, R. C. LaRocque, F. S. Midani, F. Qadri, J. Yan, A. A. Weil, W.-L. Ng

This study shows that Paracoccus aminovorans enhances Vibrio cholerae colonization in the murine intestine through dual-species biofilm formation dependent on VPS and other biofilm components.

bioRxiv · Feb 1, 2021Microbiology

Humans surviving cholera develop antibodies against Vibrio cholerae O-specific polysaccharide that inhibit pathogen motility

R. C. Charles, M. Kelly, J. M. Tam, A. Akter, M. Hossain, K. Islam, R. Biswas, M. Kamruzzaman, F. Chowdhurry, A. I. Khan, D. T. Leung, A. A. Weil, R. C. LaRocque, T. R. Bhuiyan, A. Rahman, , E. T. Ryan

This study shows that antibodies against Vibrio cholerae O-specific polysaccharide inhibit bacterial motility and provide protection against cholera in a murine model.

bioRxiv · Oct 8, 2020Microbiology

Predicting Vibrio cholerae infection and disease severity using metagenomics in a prospective cohort study

I. Levade, M. M. Saber, F. S. Midani, F. Chowdhury, A. I. Khan, Y. Begum, E. T. Ryan, L. A. David, S. B. Calderwood, J. B. Harris, R. C. LaRocque, F. Qadri, B. J. Shapiro, A. A. Weil

This study uses metagenomic sequencing to predict cholera infection and disease severity in a cohort, identifying protective bacterial species and genes.

bioRxiv · Feb 25, 2020Microbiology

Cognate T and B cell interaction and association of Follicular helper T cells with B cell responses in Vibrio cholerae O1 infected Bangladeshi adults

R. Rashu, T. R. Bhuiyan, M. R. Hoq, L. Hossain, A. Paul, A. I. Khan, F. Chowdhury, J. B. Harris, E. T. Ryan, S. B. Calderwood, A. A. Weil, F. Qadri

This study investigates the role of follicular helper T (Tfh) cells in B cell responses during Vibrio cholerae O1 infection, finding that Tfh cells expressing CD40L are associated with memory B cell responses and antibody class switching.

bioRxiv · Apr 23, 2018Immunology

Vibrio cholerae genomic diversity within and between patients

I. Levade, Y. Terrat, J.-B. Leducq, A. A. Weil, L. M. Mayo-Smith, F. Chowdhury, A. I. Khan, J. Boncy, J. Buteau, L. C. Ivers, E. T. Ryan, R. C. Charles, S. B. Calderwood, F. Qadri, J. B. Harris, , B. J. Shapiro

This study examines V. cholerae genomic diversity within and between patients, finding limited point mutations but higher gene content variation, including phage and plasmid exchanges, which may impact disease outcomes.

Microbial Genomics · Dec 7, 2017Peer-reviewedMicrobiology