F. Qadri

Diversity of Vibrio cholerae O1 through the human gastrointestinal tract during cholera

This study compares genetic diversity of Vibrio cholerae O1 in vomit and stool from cholera patients, finding reduced diversity in stool and some gene loss between samples.

Phage predation, disease severity and pathogen genetic diversity in cholera patients

A study of cholera patients in Bangladesh identifies phage predation as a biomarker of disease severity and driver of coevolution within patients.

Shigella O-specific polysaccharide functional IgA responses mediate protection against shigella infection in an endemic high-burden setting

This study identifies OSP-specific functional IgA responses as protective against shigella infection in high-burden settings by enhancing neutrophil and monocyte activation.

Reemergence of cholera in Haiti

The paper investigates the origins of a new cholera outbreak in Haiti in 2022 using genomic and phenotypic analysis of Vibrio cholerae isolates.

Development of a monoclonal antibody to a vibriophage as a proxy for Vibrio cholerae detection

This study develops a monoclonal antibody to the vibriophage ICP1 to improve cholera detection in rapid diagnostic tests by detecting the phage as a proxy for Vibrio cholerae.

Gut bacteria-derived sphingolipids alter innate immune responses to oral cholera vaccine antigens

This study links gut bacteria-derived sphingolipids to enhanced innate immune responses to an oral cholera vaccine using metagenomic and experimental approaches.

A combination of metagenomic and cultivation approaches reveals hypermutator phenotypes within Vibrio cholerae infected patients

The paper combines metagenomics and cultivation approaches to show V. cholerae hypermutator phenotypes in infected patients, with evidence of adaptive mutations and transversion mutations.

Genome-wide association studies reveal distinct genetic correlates and increased heritability of antimicrobial resistance in Vibrio cholerae under anaerobic conditions

This study shows that antimicrobial resistance in Vibrio cholerae increases under anaerobic conditions and identifies distinct genetic factors associated with resistance in these conditions.

Impact of a human gut microbe on Vibrio cholerae host colonization through biofilm enhancement

This study shows that Paracoccus aminovorans enhances Vibrio cholerae colonization in the murine intestine through dual-species biofilm formation dependent on VPS and other biofilm components.

Contribution of noncanonical antigens to virulence and adaptive immunity in human infection with enterotoxigenic E. coli

The paper identifies noncanonical antigens, EtpA and EatA, associated with ETEC virulence and immune response, suggesting their potential inclusion in vaccine design.

Humans surviving cholera develop antibodies against Vibrio cholerae O-specific polysaccharide that inhibit pathogen motility

This study shows that antibodies against Vibrio cholerae O-specific polysaccharide inhibit bacterial motility and provide protection against cholera in a murine model.

Association of poor virus specific immunoglobulin G antibodyresponses with higher viral load is seen in Bangladeshi pregnantwomen having acute Hepatitis E Genotype 1 infection

This study finds that Bangladeshi pregnant women with acute Hepatitis E Genotype 1 infection have lower IgG antibody responses and higher viral loads compared to non-pregnant women with the same infection.

Situation of antibiotic resistance in Bangladesh and its association with resistance genes for horizontal transfer

The study examines antibiotic resistance patterns and associated genes in clinical isolates from Bangladesh, finding high prevalence of MDR strains and specific resistance genes like CTXM-1 and ErmB.

Predicting Vibrio cholerae infection and disease severity using metagenomics in a prospective cohort study

This study uses metagenomic sequencing to predict cholera infection and disease severity in a cohort, identifying protective bacterial species and genes.

Cognate T and B cell interaction and association of Follicular helper T cells with B cell responses in Vibrio cholerae O1 infected Bangladeshi adults

This study investigates the role of follicular helper T (Tfh) cells in B cell responses during Vibrio cholerae O1 infection, finding that Tfh cells expressing CD40L are associated with memory B cell responses and antibody class switching.

Vibrio cholerae genomic diversity within and between patients

This study examines V. cholerae genomic diversity within and between patients, finding limited point mutations but higher gene content variation, including phage and plasmid exchanges, which may impact disease outcomes.