Author

J. B. Mendelson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Physiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:metabolism & bioenergetics· 3 Assay:proteomics· 3 Research Focus:differential expression· 2 Organism:mouse· 2 Organism:plant (other)· 2

Frequent Co-Authors

F. Kazmirczak· 5 shared K. Prins· 4 shared L. M. Hartweck· 3 shared S. Prisco· 3 shared C. Guerrero· 2 shared L. Higgins· 2 shared N. T. Vogel· 2 shared T. Markowski· 2 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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5 shared papersBiochemistry

F. Kazmirczak

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Author profile →

5 papers

Recent·Most cited

Ferroptosis Inhibition Combats Metabolic Derangements and Improves Cardiac Function in Pulmonary Artery Banded Pigs

F. Kazmirczak, R. Moon, N. Vogel, W. Tollison, M. Lahti, J. Carney, J. B. Mendelson, T. Markowski, L. Higgins, K. Murray, C. Guerrero, K. Prins

This study shows ferroptosis inhibition improves cardiac function and metabolism in a large animal model of right heart failure.

American Journal of Respiratory and Critical Care Medicine · Mar 1, 2025Peer-reviewedBiochemistry

Junctophilin-2 Regulates Mitochondrial Metabolism

S. Prisco, L. M. Hartweck, F. Kazmirczak, J. B. Mendelson, S. L. Deng, S. K. Lahiri, X. Wehrens, K. Prins

This study shows JPH2 regulates mitochondrial metabolism in the right ventricle, with gene therapy improving RV function in a rat model of RVD.

Circulation · Aug 20, 2024Peer-reviewedPhysiology

A Multi-omic and Multi-Species Analysis of Right Ventricular Failure

J. B. Mendelson, J. D. Sternbach, M. J. Doyle, L. Mills, L. M. Hartweck, W. Tollison, J. P. Carney, M. T. Lahti, R. W. Bianco, R. Kalra, F. Kazmirczak, C. Hindmarch, S. L. Archer, K. W. Prins, C. M. Martin

This study compares molecular pathways of right ventricular failure across pigs, rats, and humans using transcriptomics and proteomics, finding species-specific differences in fatty acid oxidation and electron transport chain regulation.

bioRxiv · Feb 8, 2023 · PreprintBiochemistry

Ferroptosis Integrates Mitochondrial Derangements and Pathological Inflammation to Promote Pulmonary Hypertension

F. Kazmirczak, N. T. Vogel, S. Prisco, M. T. Patterson, J. Annis, R. T. Moon, L. M. Hartweck, J. B. Mendelson, M. Kim, N. Laixto Mancripe, T. Markowski, L. Higgins, C. Guerrero, B. Kremer, M. Blake, , K. Prins

This study investigates how ferroptosis contributes to pulmonary hypertension by integrating mitochondrial dysfunction and inflammation, showing that inhibiting ferroptosis reduces disease severity.

bioRxiv · Jan 19, 2023 · PreprintBiochemistry

Intermittent Fasting Activates AMP-Kinase to Restructure Right Ventricular Lipid Metabolism and Microtubules in Two Rodent Models of Pulmonary Arterial Hypertension

F. Kazmirczak, L. Hartweck, N. T. Vogel, J. B. Mendelson, J. Park, R. M. Raveendran, J. O-Uchi, B. S. Jhun, S. Prisco, K. Prins

This study shows intermittent fasting activates AMPK in rodent PAH models, improving RV lipid metabolism, mitochondrial function, and microtubule structure.

bioRxiv · Mar 7, 2022Biochemistry