F. Kazmirczak

Ferroptosis Inhibition Combats Metabolic Derangements and Improves Cardiac Function in Pulmonary Artery Banded Pigs

This study shows ferroptosis inhibition improves cardiac function and metabolism in a large animal model of right heart failure.

Junctophilin-2 Regulates Mitochondrial Metabolism

This study shows JPH2 regulates mitochondrial metabolism in the right ventricle, with gene therapy improving RV function in a rat model of RVD.

Ketone Bodies in Right Ventricular Failure: A Unique Therapeutic Opportunity

This study investigates the effects of ketone bodies in right ventricular failure, showing improved RV function and reduced inflammation in a rat model.

A Multi-omic and Multi-Species Analysis of Right Ventricular Failure

This study compares molecular pathways of right ventricular failure across pigs, rats, and humans using transcriptomics and proteomics, finding species-specific differences in fatty acid oxidation and electron transport chain regulation.

Ferroptosis Integrates Mitochondrial Derangements and Pathological Inflammation to Promote Pulmonary Hypertension

This study investigates how ferroptosis contributes to pulmonary hypertension by integrating mitochondrial dysfunction and inflammation, showing that inhibiting ferroptosis reduces disease severity.

Intermittent Fasting Activates AMP-Kinase to Restructure Right Ventricular Lipid Metabolism and Microtubules in Two Rodent Models of Pulmonary Arterial Hypertension

This study shows intermittent fasting activates AMPK in rodent PAH models, improving RV lipid metabolism, mitochondrial function, and microtubule structure.