Author

J. C. Clements

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

A. K. Pingili· 1 shared B. J. Mendoza· 1 shared B. R. Counts· 1 shared B. Teng· 1 shared C. Cotter· 1 shared C. Trinh· 1 shared D. Daria· 1 shared D. N. Hayes· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

A. K. Pingili

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2 papers

Recent·Most cited

Potency of CRISPR-Cas Antifungals Is Enhanced by Co-targeting DNA Repair and Growth Regulatory Machinery at the Genetic Level

B. J. Mendoza, X. Zheng, J. C. Clements, C. Cotter, C. Trinh

This paper demonstrates that co-targeting essential and DNA repair genes enhances CRISPR-Cas antifungal efficacy in yeast, outperforming single-target approaches.

bioRxiv · Jul 11, 2023 · PreprintBioengineering

Response to immune checkpoint blockade improved in pre-clinical model of breast cancer after bariatric surgery

L. M. Sipe, M. Chaib, E. B. Korba, M. C. Lovely, H. Jo, B. R. Counts, U. Tanveer, J. C. Clements, N. A. John, D. Daria, T. N. Marion, R. Sekhri, A. K. Pingili, B. Teng, J. A. Carson, , L. Makowski

This study shows that bariatric surgery followed by immune checkpoint blockade improves breast cancer outcomes in formerly obese mice, despite weight loss being less effective than diet in reducing tumor burden.

bioRxiv · Mar 30, 2022Cancer Biology