Author

D. N. Hayes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2

Frequent Co-Authors

H. Jo· 2 shared L. M. Sipe· 2 shared L. Makowski· 2 shared M. Chaib· 2 shared U. Tanveer· 2 shared A. Chatterjee· 1 shared A. Horani· 1 shared A. K. Pingili· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCancer Biology

H. Jo

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Protein Kinase C Delta Regulates Mononuclear Phagocytes and Hinders Response to Immunotherapy in Cancer

M. Chaib, J. R. Holt, L. M. Sipe, M. S. Bohm, S. C. Joseph, J. Yarbro, U. Tanveer, T. J. Hollingsworth, Q. Wei, P. Thomas, D. N. Hayes, L. Makowski

This study shows that PKCδ in mononuclear phagocytes suppresses antitumor immunity and response to immunotherapy by reprogramming macrophages and dendritic cells.

bioRxiv · Mar 31, 2022Immunology

Response to immune checkpoint blockade improved in pre-clinical model of breast cancer after bariatric surgery

L. M. Sipe, M. Chaib, E. B. Korba, M. C. Lovely, H. Jo, B. R. Counts, U. Tanveer, J. C. Clements, N. A. John, D. Daria, T. N. Marion, R. Sekhri, A. K. Pingili, B. Teng, J. A. Carson, , L. Makowski

This study shows that bariatric surgery followed by immune checkpoint blockade improves breast cancer outcomes in formerly obese mice, despite weight loss being less effective than diet in reducing tumor burden.

bioRxiv · Mar 30, 2022Cancer Biology

Comparative Multiomic Analysis Reveals Low T Cell Infiltration as the Primary Feature of Tobacco Use in HPV(+) Oropharyngeal Cancer

B. M. Wahle, P. Zolkind, R. Ramirez, Z. L. Skidmore, A. Mazul, D. N. Hayes, V. C. Sandulache, W. L. Thorstad, D. Adkins, O. L. Griffith, M. Griffith, J. P. Zevallos

This study identifies low T cell infiltration as a key feature of tobacco use in HPV-positive oropharyngeal cancer, linked to worse outcomes.

bioRxiv · Mar 23, 2021 · PreprintCancer Biology

Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell

M. Puray-Chavez, K. M. Lapak, T. P. Schrank, J. L. Elliott, D. P. Bhatt, M. J. Agajanian, R. Jasuja, D. Q. Lawson, K. Davis, P. W. Rothlauf, H. Jo, N. Lee, K. Tenneti, J. E. Eschbach, C. Shema Mugisha, , S. B. Kutluay

This study identifies H522 cells as ACE2-negative human cells permissive to SARS-CoV-2 infection, revealing alternative receptor usage and host response mechanisms.

bioRxiv · Mar 1, 2021Microbiology

CRTC1-MAML2 Establishes a PGC1α-IGF1 Circuit that Confers Vulnerability to PPARγ Inhibition

A. M. Musicant, K. Parag-Sharma, W. Gong, M. Sengupta, A. Chatterjee, E. C. Henry, Y.-H. Tsai, M. Hayward, S. Sheth, R. Betancourt, T. Hackman, R. J. Padilla, J. S. Parker, J. Giudice, C. A. Flaveny, , A. L. Amelio

This study identifies a CRTC1-MAML2-driven transcriptional circuit involving PGC-14 and IGF-1 that makes mucoepidermoid carcinoma cells vulnerable to PPARγ inhibition.

bioRxiv · Jun 3, 2020 · PreprintCancer Biology