K. Kaneko

Triggered Release from Thermosensitive Liposomes Improves Tumor Targeting of Vinorelbine

This study evaluates thermosensitive liposomes with vinorelbine and mild hyperthermia for improved tumor targeting in a murine rhabdomyosarcoma model, showing enhanced therapeutic index.

Harnessing Immunotherapy to Enhance the Systemic Anti-Tumor Effects of Thermosensitive Liposomes

This study combines thermosensitive liposomes, localized hyperthermia, and immune checkpoint inhibition to enhance systemic anti-tumor effects in a murine model of rhabdomyosarcoma.

Identification of CD133+ Intercellsomes in Intercellular Communication to Offset Intracellular Signal Deficit

The paper identifies CD133+ intercellsomes as a mechanism for intercellular communication to compensate for intracellular signal deficits in stress conditions.

Comprehensive analysis of gene regulatory dynamics, fitness landscape, and population evolution during sexual reproduction

The paper analyzes gene regulatory dynamics and fitness landscapes in two-gene networks to study population evolution during sexual reproduction.

The Statistical Trends of Protein Evolution: A Lesson from AlphaFold Database

This study analyzes AlphaFold-predicted protein structures across organisms to show that higher complexity correlates with specific structural and dynamic properties and statistical structural proximity reflecting phylogenetic relationships.

Heterosis Related to Fitness and Phenotypic Variance in the Evolution of Diploid Gene Regulatory Network

This study numerically evolves diploid gene regulatory networks to show that heterozygote populations have higher fitness and lower phenotypic variance than homozygotes, linking heterosis to noise robustness and overdominance.

Chemophoresis Engine: Universal Principle of ATPase-driven Cargo Transport

The paper introduces the chemophoresis engine as a mechanism for ATPase-driven cargo transport, demonstrating its role in plasmid positioning and oscillation in bacterial cells.

Evolution of Phenotypic Plasticity under Host-Parasite Interactions

This study investigates how host-parasite interactions influence the evolution of phenotypic plasticity and robustness, finding that strong interactions increase phenotypic variance through genetic or noise-driven mechanisms.

Evolution of Mendelian dominance in gene regulatory networks associated with phenotypic robustness

This paper shows that Mendelian dominance evolves in gene regulatory networks through complex genotype-phenotype interactions, increasing phenotypic robustness to noise and genetic differences.

Entangled gene regulatory networks with cooperative expression endow robust adaptive responses to unforeseen environmental changes

The paper shows complex gene regulatory networks with cooperative expression enable robust and adaptive responses to unforeseen environmental changes through global gene expression correlations.

Dynamical Systems Approach to Evolution-Development Congruence: Revisiting Haeckel's Recapitulation Theory

The paper revisits Haeckel's recapitulation theory using dynamical systems and gene regulation networks to show congruence between evolutionary and developmental pattern changes through bifurcations.

Microbial Potlatch: Cell-level adaptation of leakiness of metabolites leads to resilient symbiosis among diverse cells

The paper shows that microbial cells evolve to leak essential metabolites, enabling mutualistic coexistence with consumer cells and leading to resilient, diverse ecosystems.

Autotoxin-mediated voluntary triage in starved yeast community

The paper shows yeast communities use autotoxins to selectively eliminate non-tagged cells during starvation, enabling survival through voluntary triage.

Functional Sensitivity and Mutational Robustness of Proteins

This study establishes a framework to analyze protein functional sensitivity and mutational robustness, revealing power-law behaviors and evolutionary constraints.

The origin of the central dogma through conflicting multilevel selection

This paper demonstrates that the central dogma of molecular biology arises from conflicting multilevel selection in a model of protocells and catalytic molecules.

Molecular Diversity and Network Complexity in Growing Protocells

This study models protocells to show how molecular diversity and complex reaction networks emerge through evolutionary processes driven by resource limitations and parasitic to host species transitions.

Anti-CD137 monoclonal antibody enhances trastuzumab-induced, natural killer cell-mediated cytotoxicity against pancreatic cancer cell lines with low human epidermal growth factor-like receptor 2 expression

This study shows that combining anti-CD137 mAb with trastuzumab enhances NK cell-mediated ADCC against HER2-low pancreatic cancer cells, particularly in individuals with FcγRIIIA-VV/VF genotype.

Formation Of Dominant Mode By Evolution In Biological Systems

The paper investigates how evolutionary robustness constrains phenotypic changes to a one-dimensional axis related to growth rate in bacterial cells.