Author

M. C. Franklin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:cryo-EM· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Research Focus:cell signaling & trafficking· 1 Organism:multiple species· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

K. Saotome· 4 shared A. J. Murphy· 3 shared G. D. Yancopoulos· 3 shared W. C. Olson· 3 shared Y. Zhou· 3 shared M. J. Moore· 2 shared A. Baum· 1 shared A. Coppola· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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4 shared papersBiochemistry

K. Saotome

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Structural insights into CXCR4 modulation and oligomerization

K. Saotome, L. L. McGoldrick, J.-H. Ho, T. F. Ramlall, S. Shah, M. J. Moore, J. H. Kim, R. Leidich, W. C. Olson, M. C. Franklin

This study uses cryoEM to reveal structural details of CXCR4 activation by CXCL12 and its oligomerization, showing new modes of GPCR regulation.

bioRxiv · Feb 9, 2024Biochemistry

Structural analysis of cancer-relevant TCR-CD3 and peptide-MHC complexes by cryoEM

K. Saotome, D. Dudgeon, K. Colotti, M. J. Moore, J. Jones, Y. Zhou, A. Rafique, G. D. Yancopoulos, A. J. Murphy, J. C. Lin, W. C. Olson, M. C. Franklin

The paper reports cryoEM structures of TCR-CD3 complexes and pMHC ligands, revealing structural insights into TCR recognition of cancer antigens.

bioRxiv · Aug 18, 2022Biochemistry

Structural insights into the assembly of gp130 family cytokine signaling complexes

Y. Zhou, P. E. Stevis, J. Cao, K. Saotome, J. Wu, A. G. Zaretsky, S. Haxhinasto, G. D. Yancopoulos, A. J. Murphy, M. W. Sleeman, W. C. Olson, M. C. Franklin

The paper determines cryo-EM structures of gp130 family cytokine signaling complexes to reveal structural insights into their assembly and biological specificity.

bioRxiv · Jun 30, 2022Biochemistry

REGEN-COV protects against viral escape in preclinical and human studies

R. Copin, A. Baum, E. Wloga, K. E. Pascal, S. Giordano, B. O. Fulton, A. Zhou, N. Negron, K. Lanza, N. Chan, A. Coppola, J. Chiu, M. Ni, G. S. Atwal, A. Romero Hernandez, , C. A. Kyratsous

This study shows that REGEN-COV, a combination of non-competing antibodies, provides broad coverage against SARS-CoV-2 variants and prevents the emergence of new variants in clinical and preclinical settings.

bioRxiv · Mar 10, 2021 · PreprintMicrobiology