Author

J. C. Newman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

B. Eap· 3 shared M. Nomura· 3 shared T. Y. Garcia· 3 shared B. Schilling· 2 shared C. D. King· 2 shared E. Verdin· 2 shared O. Panda· 2 shared S. S. Madhavan· 2 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersPhysiology

B. Eap

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A ketogenic diet reduces age-induced chronic neuroinflammation in mice

M. Nomura, N. F. Murad, S. S. Madhavan, B. Eap, T. Y. Garcia, C. G. Aguirre, E. Verdin, L. Ellerby, D. Furman, J. C. Newman

This study shows that a cyclic ketogenic diet reduces neuroinflammation in aging mice by modulating microglial responses to inflammatory stimuli.

bioRxiv · Dec 1, 2023 · PreprintImmunology

A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity

M. Alexander, V. Upadhyay, R. Rock, L. Ramirez, K. Trepka, P. Puchalska, D. Orellana, Q. Y. Ang, C. Whitty, J. A. Turnbaugh, Y. Tian, D. Dumlao, R. R. Nayak, A. D. Patterson, J. C. Newman, , P. J. Turnbaugh

This study shows that a ketogenic diet reduces autoimmune disease in mice by altering host metabolism and shaping gut microbiota, specifically through β-hydroxybutyrate and Lactobacillus species.

bioRxiv · Nov 2, 2023Microbiology

β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain

S. S. Madhavan, S. Roa Diaz, S. Peralta, M. Nomura, C. D. King, A. Lin, D. Bhaumik, S. Shah, T. Blade, W. Gray, M. Chamoli, B. Eap, O. Panda, D. Diaz, T. Y. Garcia, , J. C. Newman

This study identifies β-hydroxybutyrate as a metabolic regulator of protein solubility in aging and Alzheimer's disease, showing it reduces insolubility of pathological proteins like amyloid-β.

bioRxiv · Jul 3, 2023Physiology

Ketone body metabolism declines with age in mice in a sex-dependent manner

B. Eap, M. Nomura, O. Panda, T. Y. Garcia, C. D. King, J. P. Rose, T. C. Leone, D. P. Kelly, B. Schilling, J. C. Newman

This study shows that ketone body metabolism declines with age in mice, with sex-dependent differences in metabolic responses to a ketogenic diet.

bioRxiv · Oct 5, 2022 · PreprintPhysiology