Author

J. P. Duxin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Organism:Xenopus· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Isogawa· 1 shared A. Kettenbach· 1 shared A. O. Gao· 1 shared B. Lopez Mendez· 1 shared B. Rymarczyk· 1 shared E. P. Hertz· 1 shared I. Nasa· 1 shared J. A. Paulo· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperBiochemistry

A. Isogawa

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A complex of BRCA2 and PP2A-B56 is required for DNA repair by homologous recombination

S. M. Ambjoern, J. P. Duxin, E. P. Hertz, I. Nasa, J. Duro, T. Kruse, B. Lopez Mendez, B. Rymarczyk, L. E. Cressey, T. Hansen, A. Kettenbach, V. H. Oestergaard, M. Lisby, J. Nilsson

This study identifies the BRCA2-PP2A-B56 complex as essential for efficient DNA repair by homologous recombination and shows that cancer mutations disrupt this interaction, increasing sensitivity to PARP inhibition.

bioRxiv · Apr 10, 2021Cell Biology

Crosstalk between repair pathways elicits Double-Strand Breaks in alkylated DNA: implications for the action of temozolomide

R. P. FUCHS, A. Isogawa, J. A. Paulo, K. Onizuka, T. Takahashi, R. Amunugama, J. P. Duxin, S. Fujii

This study investigates how temozolomide induces DNA double-strand breaks through crosstalk between repair pathways in Xenopus egg extracts.

bioRxiv · Nov 21, 2020Biochemistry

The CMG helicase bypasses DNA protein cross-links to facilitate their repair

J. L. Sparks, A. O. Gao, M. Raschle, N. B. Larsen, M. Mann, J. P. Duxin, J. C. Walter

The paper shows that the CMG helicase bypasses DNA-protein cross-links without prior proteolysis, and RTEL1 aids this process and also promotes proteolysis.

bioRxiv · Jul 31, 2018Biochemistry