PHLPP1 Counter-regulates STAT1-mediated Inflammatory Signaling
K. Cohen Katsenelson, J. D. Stender, A. T. Kawashima, G. Lorden, S. Uchiyama, V. Nizet, C. K. Glass, A. C. Newton
This paper identifies PHLPP1 as a phosphatase that dephosphorylates STAT1 to regulate inflammatory signaling in macrophages, with loss of PHLPP1 protecting mice from sepsis.
bioRxiv · May 24, 2019Biochemistry