Author

A. C. Newton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Approach:biophysical modeling· 1 Research Focus:differential expression· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

A. J. Pollak· 1 shared A. McNeilly· 1 shared A. P. Kornev· 1 shared A. T. Kawashima· 1 shared C. A. Pilo· 1 shared C. A. Worby· 1 shared C. K. Glass· 1 shared C. Longman· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperBiochemistry

A. J. Pollak

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Author profile →

4 papers

Recent·Most cited

Sensitive Fluorescent Biosensor Reveals Differential Subcellular Regulation of PKC

Q. Su, J. Zhang, W. Lin, J.-f. Zhang, A. C. Newton, S. Mehta, J. Yang, J. Zhang

The paper introduces a sensitive fluorescent biosensor, ExRai-CKAR2, to study subcellular PKC activity and finds differential regulation of PKC isoforms at the ER, lysosomes, and Par complexes.

bioRxiv · Mar 29, 2024Bioengineering

Ca2+-dependent liquid-liquid phase separation underlies intracellular Ca2+ stores.

J. E. Mayfield, A. J. Pollak, C. A. Worby, J. C. Xu, V. Tandon, M. Bose, A. McNeilly, S. Banerjee, A. C. Newton

The paper identifies Ca2+-dependent liquid-liquid phase separation in CASQ1, a Ca2+ binding protein in skeletal muscle, explaining Ca2+ buffering and storage mechanisms.

bioRxiv · Jul 6, 2021 · PreprintBiochemistry

Protein Kinase C gamma Mutations Drive Spinocerebellar Ataxia Type 14 by Impairing Autoinhibition

C. A. Pilo, T. R. Baffi, A. P. Kornev, M. T. Kunkel, M. Malfavon, D.-H. Chen, L.-C. Huang, C. Longman, N. A. Kannan, W. H. Raskind, D. J. Gonzalez, S. S. Taylor, G. Gorrie, A. C. Newton

SCA14 driver mutations in PKCγ impair autoinhibition, with defect correlating inversely with age of disease onset.

bioRxiv · Jun 24, 2021 · PreprintBiochemistry

PHLPP1 Counter-regulates STAT1-mediated Inflammatory Signaling

K. Cohen Katsenelson, J. D. Stender, A. T. Kawashima, G. Lorden, S. Uchiyama, V. Nizet, C. K. Glass, A. C. Newton

This paper identifies PHLPP1 as a phosphatase that dephosphorylates STAT1 to regulate inflammatory signaling in macrophages, with loss of PHLPP1 protecting mice from sepsis.

bioRxiv · May 24, 2019Biochemistry