BiochemistrybioRxiv
PHLPP1 Counter-regulates STAT1-mediated Inflammatory Signaling
K. Cohen Katsenelson, J. D. Stender, A. T. Kawashima…·A. C. Newton
This paper identifies PHLPP1 as a phosphatase that dephosphorylates STAT1 to regulate inflammatory signaling in macrophages, with loss of PHLPP1 protecting mice from sepsis.
DOI 10.7554/elife.48609