Author

N. Thadathil

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:cancer & tumor microenvironment· 4 Research Focus:host-pathogen & immune response· 4 Assay:bulk RNA-seq· 2 Research Focus:development & morphogenesis· 2 Research Focus:cell type annotation· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

E. H. Nicklas· 5 shared S. S. Deepa· 5 shared A. Richardson· 4 shared R. Selvarani· 4 shared S. Mohammed· 4 shared B. F. Miller· 3 shared D. Wang· 3 shared A. L. Tran· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersBiochemistry

E. H. Nicklas

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Non-Necroptotic Roles of MLKL in Diet-Induced Obesity, Liver Pathology, and Insulin Sensitivity: Insights from a High Fat, High Fructose, High Cholesterol Diet Mouse Model

P. Ohene-Marfo, H. V. M. Nguyen, S. Mohammed, N. Thadathil, A. Tran, E. H. Nicklas, D. Wang, R. Selvarani, J. Farriester, R. Varshney, M. Kinter, A. Richardson, M. Rudolph, S. S. Deepa

This study investigates MLKL's non-necroptotic roles in diet-induced obesity and liver disease using a HFHFrHC mouse model, finding dose-dependent effects on inflammation and metabolic parameters.

bioRxiv · Jan 10, 2024Biochemistry

Blocking necroptosis reduces inflammation and tumor incidence in a mouse model of diet-induced hepatocellular carcinoma

S. Mohammed, N. Thadathil, A. L. Tran, M. Van Der Veldt, C. Georgescu, N. H. Haritha, P. Ohene-Marfo, S. Oh, E. H. Nicklas, D. Wang, W. Luo, R. Janknecht, B. F. Miller, J. D. Wren, W. Freeman, S. S. Deepa

bioRxiv · Aug 3, 2022 · PreprintCancer Biology

Senolytic Treatment Reduces Cell Senescence and Necroptosis in Sod1 Knockout Mice that is Associated with Reduced Inflammation and Hepatocellular Carcinoma

N. Thadathil, R. Selvarani, S. J. Mohammed, E. H. Nicklas, A. L. Tran, M. Kamal, W. Luo, J. L. Brown, M. M. Lawrence, A. K. Borowik, B. F. Miller, H. Van Remmen, A. Richardson, S. S. Deepa

bioRxiv · May 15, 2022Biochemistry

Necroptosis contributes to chronic inflammation and fibrosis in aging liver

S. Mohammed, N. Thadathil, R. Selvarani, E. H. Nicklas, D. Wang, B. F. Miller, A. Richardson, S. S. Deepa

This study shows that necroptosis increases with age in the liver, contributing to chronic inflammation and fibrosis.

bioRxiv · Sep 19, 2021Biochemistry

Role of necroptosis in chronic hepatic inflammation and liver disease in Cu/Zn superoxide dismutase deficient mice

S. Mohammed, E. H. Nicklas, N. Thadathil, R. Selvarani, G. H. Royce, A. Richardson, S. S. Deepa

This study shows that necroptosis contributes to liver inflammation, fibrosis, and HCC progression in Sod1KO mice by increasing pro-inflammatory markers and STAT3 activation.

bioRxiv · Aug 17, 2020 · PreprintBiochemistry