B. F. Miller

Metformin treatment results in distinctive skeletal muscle mitochondrial remodeling in rats with different intrinsic aerobic capacities

This study shows metformin induces different mitochondrial remodeling in rat skeletal muscle based on baseline aerobic capacity and muscle type.

Fibroblast growth factor-21 induces skeletal muscle atrophy and increases plasma amino acids in female mice: a potential role for glucocorticoids

This study shows FGF21 induces skeletal muscle atrophy and increases plasma amino acids in female mice, likely via glucocorticoid signaling and HPA axis activation.

17α-estradiol Alleviates High-Fat Diet-Induced Inflammatory and Metabolic Dysfunction in Skeletal Muscle of Male and Female Mice

This study shows 17α-estradiol improves metabolic and inflammatory outcomes in skeletal muscle of male mice but not females on a high-fat diet.

Metabolic benefits of 17α-estradiol in liver are partially mediated by ERβ in male mice

This study shows that 17α-estradiol's metabolic benefits in male mice are partially mediated by ERβ in liver, specifically affecting SCD1 and TGF-β1 production.

Skeletal muscle nuclei in mice are not post-mitotic

This study shows that skeletal muscle nuclei in mice can replicate in vivo through endoreplication, challenging the belief that they are post-mitotic.

Blocking necroptosis reduces inflammation and tumor incidence in a mouse model of diet-induced hepatocellular carcinoma

Senolytic Treatment Reduces Cell Senescence and Necroptosis in Sod1 Knockout Mice that is Associated with Reduced Inflammation and Hepatocellular Carcinoma

Necroptosis contributes to chronic inflammation and fibrosis in aging liver

This study shows that necroptosis increases with age in the liver, contributing to chronic inflammation and fibrosis.

Phytochemical Nrf2 activator attenuates skeletal muscle mitochondrial dysfunction and impaired proteostasis in a preclinical model of musculoskeletal aging

This study shows that a Nrf2 activator improves mitochondrial function and proteostasis in aging guinea pigs but does not significantly enhance mobility.