Author

J. den Hertog

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 4 Organism:bacteria (other)· 3 Research Focus:drug response / drug discovery· 2 Organism:zebrafish· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. Hoeksma· 5 shared W. A. Beenker· 3 shared H. Clevers· 2 shared X. Ouyang· 2 shared A. Bocedi· 1 shared A. Lauri· 1 shared A. Quercioli· 1 shared B. Biondi· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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5 shared papersMicrobiology

J. Hoeksma

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Establishment and characterization of a new Pseudomonas aeruginosa infection model using 2D airway organoids and dual RNA sequencing

C. Pleguezuelos-Manzano, W. A. Beenker, G. J. F. van Son, H. Beghtel, G. D. Amatngalim, J. M. Beekman, H. Clevers, J. den Hertog

This study establishes a Pseudomonas aeruginosa infection model using 2D airway organoids and dual RNA sequencing to investigate host-bacterial interactions and quorum sensing effects.

bioRxiv · Mar 11, 2023 · PreprintMicrobiology

Paecilomycone inhibits quorum sensing in Gram-negative bacteria

W. A. Beenker, J. Hoeksma, M. Marie Bannier-Helaouët, H. Clevers, J. den Hertog

This paper identifies paecilomycone as a quorum sensing inhibitor in Pseudomonas aeruginosa, reducing virulence factors and biofilm formation with low eukaryotic toxicity.

bioRxiv · Sep 12, 2022Microbiology

Harzianic Acid has multi-target antimicrobial activity against Gram-Positive Bacteria

X. Ouyang, J. Hoeksma, W. A. Beenker, S. van der Beek, J. den Hertog

This study identifies harzianic acid as a multi-target antimicrobial compound effective against Gram-positive bacteria, with resistance linked to specific gene mutations.

bioRxiv · Dec 3, 2021 · PreprintMicrobiology

Time-lapse imaging of bacterial morphology facilitates classification of antimicrobial agents

X. Ouyang, J. Hoeksma, T. K. Siersma, L. W. Hamoen, J. den Hertog

The paper introduces a time-lapse imaging method to classify antimicrobial agents based on their effects on bacterial morphology.

bioRxiv · Sep 8, 2021 · PreprintMicrobiology

Targeting Oncogenic Src Homology 2 Domain-Containing Phosphatase 2 (SHP2) by Inhibiting its Protein-Protein Interactions

S. Bobone, L. Pannone, B. Biondi, M. Solman, E. Flex, V. Canale, P. Calligari, C. De Faveri, T. Gandini, A. Quercioli, G. Torini, M. Venditti, A. Lauri, G. Fasano, J. Hoeksma, , L. Stella

This study develops peptide-based SHP2 inhibitors that target protein-protein interactions, showing higher affinity for pathogenic variants and efficacy in zebrafish embryos.

bioRxiv · Aug 28, 2020Biophysics

Cercosporamide inhibits bone morphogenetic protein receptor type I kinase activity in zebrafish

J. Hoeksma, G. C. M. van der Zon, P. ten Dijke, J. den Hertog

This study identifies cercosporamide as a BMP type I receptor kinase inhibitor that rescues developmental defects in zebrafish embryos.

bioRxiv · May 29, 2020Pharmacology & Toxicology