The paper shows that PTEFb enables rapid transcriptional reorganization in glioma cells after radiotherapy, enhancing survival, and that inhibiting PTEFb reduces this response and increases cell death.

bioRxiv · Jan 24, 2023 · PreprintCancer Biology

Mapping pediatric brain tumors to their origins in the developing cerebellum

K. Okonechnikov, P. Joshi, M. Sepp, K. Leiss, I. Sarropoulos, F. Murat, M. Sill, P. Beck, K. C.-H. Chan, A. Korshunov, F. Sahm, M. Y. Deng, D. Sturm, J. DeSisto, A. M. Donson, , S. M. Pfister

The paper maps the cellular origins of three common pediatric brain tumors using a single-nucleus atlas and transcriptome data, identifying lineage-specific origins and potential therapeutic targets.

bioRxiv · Dec 19, 2021Cancer Biology

Neoplastic and Immune single cell transcriptomics define subgroup-specific intra-tumoral heterogeneity of childhood medulloblastoma.

K. A. Riemondy, S. Venkataraman, N. Willard, A. Nellan, B. Sanford, A. M. Griesinger, V. Amani, S. Mitra, T. C. Hankinson, M. H. Handler, M. Sill, J. Ocasio, S. J. Weir, D. S. Malawsky, T. R. Gershon, , R. Vibhakar

The paper uses single-cell transcriptomics to identify subgroup-specific neoplastic and immune cell heterogeneity in childhood medulloblastoma.

bioRxiv · Aug 28, 2020Cancer Biology

Super elongation complex as a targetable dependency in diffuse midline glioma

N. A. Dahl, E. Danis, I. Balakrishnan, D. Wang, A. Pierce, F. Walker, A. Gilani, N. Serkova, K. Madhaven, S. Fosmire, A. Green, N. K. Foreman, S. Venkataraman, R. Vibhakar

This study identifies AFF4 as a therapeutic target in diffuse midline glioma by showing CDK9 inhibitors inhibit the super elongation complex and induce anti-tumor effects.

bioRxiv · Jan 22, 2020Cancer Biology