Author

J. Dupuy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Organism:rat· 1 Assay:structural biology· 1

Frequent Co-Authors

F. Gueraud· 2 shared A. Girault· 1 shared A. J. Garcia-Saez· 1 shared A. Le Pape· 1 shared A. Lefevre· 1 shared A. Promeyrat· 1 shared A. Robert· 1 shared A. Vermot· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersPathology

F. Gueraud

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

X-Ray Structure and enzymatic study of a Bacterial NADPHoxidase highlight the activation mechanism of eukaryoticNOX

I. Petit-Hartlein, A. Vermot, M. Thepaut, A.-S. Humm, F. Dupeux, J. Dupuy, V. Chaptal, J. A. Marquez, S. M. E. Smith, F. Fieschi

The paper presents crystal structures of SpNOX and its DH domain, revealing the activation mechanism of eukaryotic NOX by elucidating hydride transfer and flavin binding.

bioRxiv · Oct 16, 2023Biochemistry

Reduction, removal or replacement of sodium nitrite in a model of cured and cooked meat: a joint evaluation of consequences on microbiological issues in food safety, colon ecosystem and colorectal carcinogenesis

F. Gueraud, C. Buisson, A. Promeyrat, N. Naud, E. Fouche, V. Bezirard, J. Dupuy, P. Plaisancie, C. Helies-Toussaint, L. Trouilh, J.-L. Martin, S. Jeuge, E. Keuleyan, N. Petit, L. Aubry, , F. H. PIERRE

This study evaluates the effects of sodium nitrite reduction, removal, and replacement in ham on microbiological safety, colon health, and colorectal cancer risk in a rat model.

bioRxiv · Mar 24, 2023 · PreprintPathology

Curcumin and NCLX Inhibitors Share Anti-Tumoral Mechanisms in Microsatellite-Instability-Driven Colorectal Cancer

M. Gueguinou, S. Ibrahim, J. Bourgeais, A. Robert, T. Pathak, X. Zhang, D. Crottes, J. Dupuy, D. Ternant, V. Monbet, R. Guibon, H. Flores-Romero, A. Lefevre, S. Lerondel, A. Le Pape, , T. Lecomte

This study identifies NCLX as a therapeutic target in MSI-driven CRC, showing that curcumin and NCLX inhibitors induce anti-tumoral effects through mitochondrial calcium overload and apoptosis.

bioRxiv · Jan 18, 2022Cancer Biology