F. Fieschi

The human and mouse dendritic cell receptor DCIR binds to LRP1 N-glycans containing terminal galactoses, including the α-Gal antigen

This study identifies LRP1 N-glycans with terminal galactoses as ligands for DCIR, revealing its specificity in immune regulation and potential therapeutic applications.

X-Ray Structure and enzymatic study of a Bacterial NADPHoxidase highlight the activation mechanism of eukaryoticNOX

The paper presents crystal structures of SpNOX and its DH domain, revealing the activation mechanism of eukaryotic NOX by elucidating hydride transfer and flavin binding.

The unique three-dimensional arrangement of Macrophage Galactose Lectin enables E. coli LipoPolySaccharides recognition through two distinct interfaces

The paper identifies two distinct glycan binding interfaces on Macrophage Galactose Lectin that enable high-affinity recognition of E. coli LipoPolySaccharides, independent of the canonical calcium-dependent site.

Rational control of structural off-state heterogeneity in a photoswitchable fluorescent protein provides switching contrast enhancement

This paper enhances switching contrast in photoswitchable fluorescent proteins by modifying the V151 side chain, improving performance in RESOLFT nanoscopy.

Immunization with synthetic SARS-CoV-2 S glycoprotein virus-like particles protects Macaques from infection

This study develops a synthetic SARS-CoV-2 S glycoprotein virus-like particle vaccine that protects macaques from infection through strong antibody and T cell responses.

DC/L-SIGN recognition of spike glycoprotein promotes SARS-CoV-2 trans-infection and can be inhibited by a glycomimetic antagonist

The paper shows DC/L-SIGN receptors on antigen-presenting cells enhance SARS-CoV-2 trans-infection, which can be blocked by a glycomimetic compound.

Development Of C-Type Lectin Oriented Surfaces For High Avidity Glycoconjugates: Towards Mimicking Multivalent Interactions On The Cell Surface

This paper develops SPR direct interaction assays for DC-SIGN to better assess multivalent glycocluster binding, showing that scaffold architecture, valency, and glycomimetic ligands are critical for achieving nanomolar affinities.