R. Goswami

A large-scale crowd-sourced annotated acoustic dataset of Indian fauna

The paper creates a crowd-sourced acoustic dataset of Indian fauna to support biodiversity monitoring and deep learning applications in conservation.

A novel HIV triple broadly neutralizing antibody (bNAb) combination-based passive immunization of infant rhesus macaques achieves durable protective plasma neutralization levels and mediates anti-viral effector functions.

This study evaluates a triple bNAb combination in infant rhesus macaques, showing durable neutralization and effector functions with high predicted prevention efficacy against HIV strains.

Commensal bacteria inhibit viral infections via a tryptophan metabolite

The paper identifies a mechanism by which commensal bacteria inhibit viral infections through a tryptophan metabolite that activates the aryl hydrocarbon receptor.

Cell viscosity influences hematogenous dissemination and metastatic extravasation of tumor cells

This study shows that tumor cell viscosity affects their ability to circulate and extravasate, influencing metastasis.

Endothelial calcium firing mediates extravasation of metastatic tumor cells.

This study identifies endothelial calcium signaling as a key driver of tumor cell extravasation through mechanistic and imaging analyses in zebrafish embryos.

Optical characterization of molecular interaction strength in protein condensates

The paper introduces optical techniques to measure molecular interaction strength and physical properties of protein condensates, showing how sequence variations and environmental factors affect these properties.

Deep computer vision reveals the mediation of thermal-melanism and body size by precipitation and sex in a threatened alpine butterfly, Parnassius smintheus

The paper uses deep computer vision to analyze how precipitation and sex influence body size and melanism in Parnassius smintheus, finding sex-specific responses to environmental factors.

High-throughput viscoelastic characterization of cells in hyperbolic microchannels

This paper introduces hyperbolic microchannels for high-throughput viscoelastic measurement of cells and soft particles, showing accurate recovery of mechanical properties under controlled stress.

Calcitriol impairs the secretion of IL-4 and IL-13 in Th2 cells via modulating VDR-Gata3-Gfi1 axis

Viscoelastic properties of suspended cells measured with shear flow deformation cytometry

This paper introduces a microfluidic method to measure viscoelastic properties of suspended cells using shear flow deformation cytometry and demonstrates cell cycle-dependent rheological behavior.

Oral Hsp90 inhibitor, SNX-5422, attenuates SARS-CoV-2 replication and dampens inflammation in airway cells.

This study shows that the Hsp90 inhibitor SNX-5422 reduces SARS-CoV-2 replication and inflammation in airway cells, suggesting its potential as an early therapeutic.

Using real-time fluorescence and deformability cytometry and deep learning to transfer molecular specificity to label-free sorting

Analytical treatment interruption after short-term anti-retroviral therapy in a postnatally SHIV infected infant rhesus macaque model

This paper develops an infant rhesus macaque model of SHIV infection and analytical treatment interruption to study viral rebound and identify biomarkers for pediatric HIV functional cure strategies.

Oral clade C SHIV challenge models to study pediatric HIV-1 infection by breastmilk transmission

This paper evaluates three clade C SHIVs for oral transmission and infection in infant rhesus macaques, finding varied chronic viremia levels and seroconversion thresholds.

SHIV.CH505-infected infant and adult rhesus macaques exhibit similar HIV Env-specific antibody kinetics, despite distinct T-follicular helper (Tfh) and germinal center B cell landscapes

This study compares HIV-specific antibody kinetics in infant and adult rhesus macaques infected with SHIV, finding similar antibody responses despite differences in Tfh and germinal center B cell dynamics.

IgG is differentially and selectively transferred across the placenta in HIV-infected women

This study identifies factors affecting placental IgG transfer efficiency in HIV-infected women, showing that maternal disease progression and Fc region characteristics influence selective transfer of antigen-specific IgG.

Polyacrylamide Bead Sensors for in vivo Quantification of Cell-Scale Stress in Zebrafish Development

The paper develops PAAm bead sensors to measure cell-scale stress in zebrafish embryos and uses COMPAX to detect stress patterns during development.

Standardized microgel beads as elastic cell mechanical probes

This paper presents standardized poly-acylamide microgel beads as mechanical probes for cell mechanics, showing they can be calibrated to mimic cell elasticity and used for cross-comparison of measurement techniques.

Polyclonal HIV envelope-specific breast milk antibodies limit founder SHIV acquisition and cell-associated virus loads in infant rhesus monkeys.

This study shows that a tri-mAb cocktail of HIV envelope-specific antibodies reduces SHIV acquisition and viral loads in infant rhesus monkeys.