Author

C. LaBranche

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 10 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 8 Assay:proteomics· 5 Research Focus:cell type annotation· 4 Research Focus:differential expression· 3 Organism:human· 3 Organism:rat· 3 Research Focus:cell-cell communication· 2

Frequent Co-Authors

D. Montefiori· 7 shared R. W. Sanders· 5 shared A. B. Ward· 4 shared G. Ozorowski· 4 shared D. C. Montefiori· 3 shared J. P. Moore· 3 shared S. R. Permar· 3 shared A. Antanasijevic· 2 shared

Activity by Year

2017-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

7 shared papersImmunology

D. Montefiori

Mutual co-authors in cluster

Author profile →

11 papers

Recent·Most cited

Adjuvants influence the maturation of VRC01-like antibodies during immunization

M. L. Kudsen, P. Agrawal, A. MacCamy, R. K. Parks, M. D. Gray, B. Takushi, A. Khechaduri, R. Coler, C. LaBranche, D. Montefiori, L. Stamatatos

The study examines how three adjuvants affect the mutation patterns and antibody titers of VRC01-class BCRs during immunization with specific immunogens.

bioRxiv · Jun 10, 2022Immunology

CD4 binding-site antibodies induced by a subtype B HIV-1 envelope trimer

A. Schorcht, T. L. G. M. van den Kerkhof, J. Torres, E. Schermer, C. LaBranche, I. Bontjer, M. Brinkkemper, N. Gulzar, A. X. Han, J. Burger, G. Ozorowski, J. Scott, H. Schuitemaker, D. Montefiori, M. van Gils, , R. W. Sanders

This study shows that immunization with native-like HIV-1 subtype B Env trimers can induce CD4bs-directed broadly neutralizing antibodies in rabbits.

bioRxiv · Mar 23, 2022 · PreprintImmunology

Vertical HIV-1 transmission in the setting of maternal broad and potent antibody responses

J. Tu, A. Kumar, E. Giorgi, J. A. Eudailey, C. LaBranche, D. Martinez, G. G. Fouda, Y. Moreau, A. Thomas, D. Montefiori, F. Gao, M. Sagar, S. R. Permar

This study examines maternal broadly neutralizing antibody (bnAb) specificities in HIV-transmitting and non-transmitting mothers to determine if certain bnAb specificities drive infant transmitted/founder virus selection.

bioRxiv · Feb 3, 2022Immunology

Persistent Immunogenicity of Integrase Defective Lentiviral Vectors delivering membrane tethered Native-Like HIV-1 Envelope Trimers

A. Gallinaro, M. F. Pirillo, Y. Aldon, S. Cecchetti, Z. Michelini, A. Tinari, M. Borghi, A. Canitano, P. F. McKay, R. Bona, M. F. Vescio, F. Grasso, M. Blasi, S. Baroncelli, G. Scarlatti, , A. Cara

This study shows that IDLV vectors with membrane-tethered native-like HIV-1 Env trimers induce faster and longer-lasting anti-Env IgG responses in mice and macaques, with some animals developing neutralization activity against HIV-1.

bioRxiv · Oct 8, 2021Immunology

Changes at V2 apex of HIV-1 Clade C trimer enhance elicitation of autologous neutralizing and broad V1V2-scaffold antibodies

A. Sahoo, E. A. Hodge, C. LaBranche, T. T. Styles, X. Shen, N. Cheedarla, A. Shiferaw, G. Ozorowski, W.-H. Lee, A. B. Ward, G. D. Tomaras, D. C. Montefiori, D. J. Irvine, K. K. Lee, R. R. Amara

bioRxiv · Jun 15, 2021 · PreprintImmunology

Frequent development of broadly neutralizing antibodies in early life in a large cohort of HIV-infected children

G. G. Fouda, A. Lucier, Y. Fong, S. H. Li, M. Dennis, J. Eudailey, A. Nelson, K. Saunders, C. K. Cunningham, E. McFarland, R. McKinney, M. A. Moody, C. LaBranche, D. Montefiori, S. R. Permar

This study finds that HIV-infected children aged 1-3 years develop broadly neutralizing antibodies with breadth comparable to adults, and overall higher than adults, suggesting early life immune advantages for HIV vaccine development.

bioRxiv · May 7, 2021Immunology

Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM

A. Antanasijevic, L. M. Sewall, C. A. Cottrell, D. G. Carnathan, L. E. Jimenez, J. T. Ngo, J. B. Silverman, B. Groschel, E. Georgeson, J. Bhiman, R. Bastidas, C. LaBranche, J. D. Allen, J. Copps, H. R. Perrett, , A. B. Ward

The paper uses cryoEM to analyze polyclonal antibody responses to HIV Env immunogens in rhesus macaques, revealing structural differences in antibody binding and immunogenicity of engineered mutations and glycan sites.

bioRxiv · Jan 28, 2021Immunology

Immunofocusing and enhancing autologous Tier-2 HIV-1 neutralization by displaying Env trimers on two-component protein nanoparticles

P. J. M. Brouwer, A. Antanasijevic, M. de Gast, J. D. Allen, J. D. Allen, T. P. L. Bijl, A. Yasmeen, R. Ravichandran, J. Burger, G. Ozorowski, J. L. Torres, C. LaBranche, D. Montefiori, R. P. Ringe, M. van Gils, , R. W. Sanders

This study shows that displaying HIV-1 Env trimers on two-component protein nanoparticles enhances autologous Tier-2 neutralizing antibody titers in rabbits.

bioRxiv · Nov 30, 2020Microbiology

Immunogenicity, safety and efficacy of sequential immunizations with an SIV-based IDLV expressing CH505 Envs

M. Blasi, D. Negri, K. O. Saunders, E. J. Baker, H. Stadtler, C. LaBranche, B. Mildenberg, G. Morton, A. Ciarla, X. Shen, Y. Wang, W. Rountree, B. Balakumaran, S. Santra, B. F. Haynes, , M. E. Klotman

This study evaluates an SIV-based IDLV vaccine expressing sequential CH505 Envs in rhesus macaques, showing improved antibody responses and virus control but no broadly neutralizing antibodies.

bioRxiv · Mar 6, 2020Immunology

Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates

C. A. Cottrell, J. van Schooten, C. A. Bowman, M. Yuan, D. Oyen, M. Shin, R. Morpurgo, P. van der Woude, M. van Breemen, J. L. Torres, R. Patel, J. Gross, L. M. Sewall, J. Copps, G. Ozorowski, , M. J. van Gils

This study maps antibody responses to HIV-1 envelope trimers in non-human primates, identifying strain-specific and conserved epitopes recognized by vaccine-induced antibodies.

bioRxiv · Feb 5, 2020Immunology

Polyclonal HIV envelope-specific breast milk antibodies limit founder SHIV acquisition and cell-associated virus loads in infant rhesus monkeys.

J. E. Himes, R. Goswami, R. J. Mangan, A. Kumar, T. L. Jeffries, J. A. Eudailey, H. Heimsath, Q. N. Nguyen, J. Pollara, C. LaBranche, M. Chen, N. A. Vandergrift, J. W. Peacock, F. Schiro, C. Midkiff, , S. R. Permar

This study shows that a tri-mAb cocktail of HIV envelope-specific antibodies reduces SHIV acquisition and viral loads in infant rhesus monkeys.

bioRxiv · Jun 3, 2017Immunology