Author

J. E. Ippolito

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

J. B. Rubin· 2 shared J. Luo· 2 shared J. Sponagel· 2 shared A. Mauguen· 1 shared C. Frankfater· 1 shared D. R. Spitz· 1 shared E. Nunez· 1 shared G. J. Patti· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

J. B. Rubin

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2 papers

Recent·Most cited

De novo serine biosynthesis from glucose predicts sex-specific response to antifolates in non-small cell lung cancer cell lines

J. Sponagel, S. Devarakonda, J. B. Rubin, J. Luo, J. E. Ippolito

The paper shows male NSCLC cells produce more serine from glucose and are more sensitive to pemetrexed than female cells, suggesting sex differences in antifolate response.

bioRxiv · Dec 22, 2021Cancer Biology

Sex Differences in Brain Tumor Glutamine Metabolism Reveal Sex-Specific Vulnerabilities to Treatment

J. Sponagel, J. K. Jones, C. Frankfater, S. Zhang, O. Tung, K. Cho, K. L. Tinkum, H. Gass, E. Nunez, D. R. Spitz, P. Chinnaiyan, J. Schaefer, G. J. Patti, M. S. Graham, A. Mauguen, , J. E. Ippolito

The paper identifies sex differences in glutamine metabolism in glioblastomas, showing male tumors have higher glutamine uptake and are more sensitive to GLS1 inhibition than female tumors.

bioRxiv · Sep 29, 2021Cancer Biology