Sex Differences in Brain Tumor Glutamine Metabolism Reveal Sex-Specific Vulnerabilities to Treatment
J. Sponagel, J. K. Jones, C. Frankfater, S. Zhang, O. Tung, K. Cho, K. L. Tinkum, H. Gass, E. Nunez, D. R. Spitz, P. Chinnaiyan, J. Schaefer, G. J. Patti, M. S. Graham, A. Mauguen, , J. E. Ippolito
The paper identifies sex differences in glutamine metabolism in glioblastomas, showing male tumors have higher glutamine uptake and are more sensitive to GLS1 inhibition than female tumors.
bioRxiv · Sep 29, 2021Cancer Biology