Author

J. Sponagel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

J. B. Rubin· 3 shared J. Luo· 3 shared J. E. Ippolito· 2 shared A. H. Kim· 1 shared A. Mauguen· 1 shared C. Frankfater· 1 shared C. M. Hill· 1 shared D. D. Mao· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersCancer Biology

J. B. Rubin

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Author profile →

3 papers

Recent·Most cited

Gonadal sex patterns p21-induced cellular senescence in mouse and human glioblastoma

L. Broestl, L. Grandison, S. Shenoy, M. M. Tallman, G. Rhee, W. Yang, J. Sponagel, N. Kfoury-Beaumont, C. M. Hill, D. D. Mao, A. H. Kim, S. A. Stewart, M. Venere, J. Luo, J. B. Rubin

The paper shows that gonadal sex influences p21-induced cellular senescence in GBM, contributing to sex differences in survival.

Communications Biology · Aug 2, 2022Peer-reviewedCancer Biology

De novo serine biosynthesis from glucose predicts sex-specific response to antifolates in non-small cell lung cancer cell lines

J. Sponagel, S. Devarakonda, J. B. Rubin, J. Luo, J. E. Ippolito

The paper shows male NSCLC cells produce more serine from glucose and are more sensitive to pemetrexed than female cells, suggesting sex differences in antifolate response.

bioRxiv · Dec 22, 2021Cancer Biology

Sex Differences in Brain Tumor Glutamine Metabolism Reveal Sex-Specific Vulnerabilities to Treatment

J. Sponagel, J. K. Jones, C. Frankfater, S. Zhang, O. Tung, K. Cho, K. L. Tinkum, H. Gass, E. Nunez, D. R. Spitz, P. Chinnaiyan, J. Schaefer, G. J. Patti, M. S. Graham, A. Mauguen, , J. E. Ippolito

The paper identifies sex differences in glutamine metabolism in glioblastomas, showing male tumors have higher glutamine uptake and are more sensitive to GLS1 inhibition than female tumors.

bioRxiv · Sep 29, 2021Cancer Biology