Author

J. E. McLaren

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

D. A. Price· 2 shared K. Ladell· 2 shared A. J. McMichael· 1 shared A. K. Sewell· 1 shared A. N. Davydov· 1 shared D. M. Chudakov· 1 shared E. Brenna· 1 shared H. A. van den Berg· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersImmunology

D. A. Price

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2 papers

Recent·Most cited

CD8 coreceptor-mediated focusing can reorder the agonist hierarchy of peptide ligands recognized via the T cell receptor

M. Clement, L. Knezevic, T. Dockree, J. E. McLaren, K. Ladell, K. Miners, S. Llewellyn-Lacey, O. Francis, A. K. Sewell, J. S. Bridgeman, D. A. Price, H. A. van den Berg, L. Wooldridge

The paper shows that CD8 coreceptor interactions can alter the agonist hierarchy of peptide ligands recognized by TCRs, affecting antigen sensitivity without changing TCR structure.

bioRxiv · Sep 23, 2020Immunology

CD4+ T follicular helper (Tfh) cells in human tonsil and blood are clonally convergent, but divergent from non-Tfh CD4+ cells

E. Brenna, A. N. Davydov, K. Ladell, J. E. McLaren, P. Bonaiuti, M. Metsger, S. C. Gilbert, T. Lambe, D. A. Price, S. L. Campion, D. M. Chudakov, P. Borrow, A. J. McMichael

The paper examines clonal relationships between Tfh cells in blood and tonsil, finding clonal convergence between peripheral and tonsillar Tfh cells but divergence from non-Tfh CD4+ cells.

bioRxiv · Aug 22, 2019Immunology