M. Clement

Involvement of an IgE/Mast cell/B cell amplification loop in abdominal aortic aneurysm progression

This study identifies an IgE/mast cell/B cell amplification loop that drives abdominal aortic aneurysm progression by promoting IL-4 production and subclinical fissure healing impairment.

Inhibitory IL-10-producing CD4+ T cells develop in a T-bet-dependent manner and facilitate cytomegalovirus persistence via coexpression of arginase-1

The paper identifies IL-10-producing CD4+ T cells that develop via T-bet dependence and Arg1 coexpression, promoting cytomegalovirus persistence.

IFITM3 regulates virus-induced inflammatory cytokine production by titrating Nogo-B orchestration of TLR responses

This study shows IFITM3 limits viral pathogenesis by regulating Nogo-B-mediated TLR responses and cytokine production in dendritic cells.

Genome-wide DNA methylation predicts environmentally-driven life history variation in a marine fish

This study shows that DNA methylation patterns differ between two life history strategies in capelin, suggesting epigenetic changes, not genetic differences, drive these variations.

Optimal CD8+ T-cell memory formation following subcutaneous cytomegalovirus infection requires virus replication but not early dendritic cell responses

CD8 coreceptor-mediated focusing can reorder the agonist hierarchy of peptide ligands recognized via the T cell receptor

The paper shows that CD8 coreceptor interactions can alter the agonist hierarchy of peptide ligands recognized by TCRs, affecting antigen sensitivity without changing TCR structure.

Deep ancestral introgression shapes evolutionary history of dragonflies and damselflies

The paper investigates introgression in dragonflies and damselflies, showing it is widespread and has shaped their evolutionary history, including deep ancestral introgression between superfamily lineages.