S. Llewellyn-Lacey

Immortalization and Functional Screening of Natively Paired Human T Cell Receptor Repertoires

The paper develops a high-throughput method to functionally evaluate natively paired human T cell receptors against multiple pMHCs, validated through affinity-based mapping and sequencing.

Altered basal lipid metabolism underlies the functional impairment of naive CD8+ T cells in elderly humans

This study identifies age-related alterations in basal lipid metabolism of naive CD8+ T cells in elderly humans, which impair their function and can be partially reversed with lipid-altering drugs.

CD8 coreceptor-mediated focusing can reorder the agonist hierarchy of peptide ligands recognized via the T cell receptor

The paper shows that CD8 coreceptor interactions can alter the agonist hierarchy of peptide ligands recognized by TCRs, affecting antigen sensitivity without changing TCR structure.

Ex vivo detection of SARS-CoV-2-specific CD8+ T cells: rapid induction, prolonged contraction, and formation of functional memory

This study identifies SARS-CoV-2-specific CD8+ T-cell responses, showing their rapid induction, prolonged contraction, and functional memory formation compared to antibody responses.

The identity of human tissue-emigrant CD8+ T cells

The paper characterizes tissue-emigrant CD8+ T cells in humans and non-human primates, revealing distinct migratory behaviors and clonal dynamics.

Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19

The paper maps SARS-CoV-2-specific T cell responses in individuals with asymptomatic/mild COVID-19 and finds robust memory T cell responses similar to vaccines, detectable even in antibody-seronegative individuals.

Identification of a lymphocyte minor histocompatibility antigen in Mauritian cynomolgus macaques

The paper identifies a minor histocompatibility antigen in Mauritian cynomolgus macaques using alloimmunization, exome sequencing, and bioinformatics, showing its potential as a target for HIV immunotherapies.