Author

S. Mahmood

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Physiology· 2 Cancer Biology· 1 Evolutionary Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 4 Research Focus:cell type annotation· 3 Organism:chicken / avian· 3 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 2 Organism:human· 2

Frequent Co-Authors

J. James· 3 shared M. J. Slomka· 3 shared S. M. Brookes· 3 shared B. Mollett· 2 shared D. Thompson· 2 shared J. E. Sealy· 2 shared J.-R. Sadeyen· 2 shared M. Iqbal· 2 shared

Activity by Year

2016-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersMicrobiology

J. James

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Evaluating the epizootic and zoonotic threat of an H7N9 low pathogenicity avian influenza virus (LPAIV) variant associated with enhanced pathogenicity in turkeys

J. James, S. S. Thomas, A. H. Seekings, S. Mahmood, M. Kelly, A. C. Banyard, A. Nunez, S. M. Brookes, M. J. Slomka

This study evaluates the increased pathogenicity and zoonotic potential of an H7N9 LPAIV variant in turkeys, showing enhanced virulence and transmission risks.

bioRxiv · Apr 16, 2024 · PreprintMicrobiology

Hydroxysteroid 17-beta dehydrogenase 13 (Hsd17b13) knockdown attenuates liver steatosis in high-fat diet obese mice

S. Mahmood, N. Z. Morrice, D. Thompson, S. Milanizadeh, S. Wilson, P. D. Whitfield, G. D. Mcilroy, J. J. Rochford, N. Mody

This study shows that knocking down Hsd17b13 in obese mice reduces liver steatosis and improves liver health markers, suggesting HSD17B13 as a therapeutic target for MASLD.

bioRxiv · Feb 27, 2024 · PreprintPhysiology

Lineage plasticity enables low-ER luminal tumors to evolve and gain basal-like traits

G. A. Mohamed, S. Mahmood, N. B. Ognjenovic, M. K. Lee, O. M. Wilkins, B. C. Christensen, K. E. Muller, D. R. Pattabiraman

The paper shows low-ER luminal breast tumors can evolve into basal-like traits through lineage plasticity, with SOX10 identified as a potential driver.

bioRxiv · Nov 25, 2022Cancer Biology

The origin of internal genes contributes to the replication and transmission fitness of H7N9 avian influenza virus

J. James, S. Bhat, S. K. Walsh, H. M. T. K. Karunarathna, J.-R. Sadeyen, P. Chang, J. E. Sealy, S. Mahmood, B. Mollett, M. J. Slomka, S. M. Brookes, M. Iqbal

This study shows that internal gene segments from different H9N2 lineages affect the replication and transmission fitness of H7N9 avian influenza viruses in chickens and their zoonotic potential.

bioRxiv · Aug 17, 2022Microbiology

Fenretinide inhibits obesity and fatty liver disease but induces Smpd3 to increase serum ceramides and worsen atherosclerosis in LDLR-/- mice.

D. Thompson, S. Mahmood, N. Morrice, S. Kamli-Salino, R. Dekeryte, P. Hoffmann, M. K. Doherty, P. D. Whitfield, M. Delibegovic, N. Mody

This study shows that fenretinide reduces obesity and fatty liver but increases ceramides via Smpd3, worsening atherosclerosis in LDLR-/- mice.

bioRxiv · Jul 22, 2022Physiology

Extremely reduced supergroup F Wolbachia: transition to obligate insect symbionts

S. Mahmood, E. Novakova, J. Martinu, O. Sychra, V. Hypsa

This study presents genomic data for five new Wolbachia Supergroup F strains, revealing genomic features of their transition to mutualism, including gene deactivation and genome reduction.

bioRxiv · Oct 15, 2021 · PreprintEvolutionary Biology

Co-infection of chickens with H9N2 and H7N9 avian influenza viruses leads to emergence of reassortant H9N9 virus with increased fitness for poultry and enhanced zoonotic potential

S. Bhat, J. James, J.-R. Sadeyen, S. Mahmood, H. Heverest, P. Chang, S. Walsh, A. M. Byrne, B. Mollett, F. Lean, J. E. Sealy, H. Shelton, M. J. Slomka, S. M. Brookes, M. Iqbal

bioRxiv · Apr 5, 2021Microbiology

Recent thymic emigrants produce antimicrobial IL-8, express complement receptors and are precursors of a tissue-homing Th8 lineage of memory cells

M. L. Pekalski, A. Rubio Garcia, R. C. Ferreira, D. B. Rainbow, D. J. Smyth, M. Mashar, J. Brady, N. Savinykh, X. Castro Dopico, S. Mahmood, S. Duley, H. E. Stevens, N. M. Walker, A. J. Cutler, F. Waldron-Lynch, , L. S. Wicker

The paper identifies CR2+ naive T cells as recent thymic emigrants that express antimicrobial IL-8 and complement receptors, and may become tissue-homing memory cells.

bioRxiv · Jun 17, 2016Immunology