The paper identifies a conserved population of MHC-II restricted, innate-like T cells in the gut of humans and mice that react to commensals and are implicated in colitis.

bioRxiv · Sep 26, 2022 · PreprintImmunology

MR1 dependent MAIT cell activation is regulated by autophagy associated proteins

P. Phalora, J. E. Ussher, S. Hester, E. Marchi, J. Y. W. Mak, D. P. Fairlie, P. Klenerman

The paper identifies SQSTM1/p62 as an MR1 interacting protein and shows its role in regulating MAIT cell activation through autophagy pathways.

bioRxiv · Sep 20, 2022 · PreprintCell Biology

Innate triggering and antiviral effector functions of activin A

K. Al-Hourani, N. Ramamurthy, E. Marchi, R. M. Eichinger, L. N. Lee, P. Fabris, P. Klenerman, A. H. Drakesmith

This study identifies activin A as a cytokine triggered alongside type I IFN during viral infection, with antiviral effects in both in vitro and in vivo models.

bioRxiv · Mar 23, 2021Immunology

Expression of type I interferon-associated genes at antiretroviral therapy interruption predicts HIV virological rebound

P. Zacharopoulou, E. Marchi, A. Ogbe, N. Robinson, H. Brown, M. Jones, L. Parolini, M. Pace, N. Grayson, P. Kaleebu, H. Rees, S. Fidler, P. Goulder, P. Klenerman, J. Frater

The paper identifies type I interferon-associated gene expression in CD4 T cells as a predictor of delayed HIV viral rebound after antiretroviral therapy interruption.

bioRxiv · Nov 24, 2020 · PreprintMicrobiology

Hypoxic gene expression in chronic hepatitis B infected patients is not observed in state-of-art in vitro and mouse infection models

P. J. Liu, J. M. Harris, E. Marchi, V. D'Arienzo, T. Michler, P. A. Wing, A. Magri, A. Otega-Prieto, M. Van de Klundert, J. Wettengel, D. Durantel, M. Dorner, P. Klenerman, U. Protzer, S. Giotis, J. A. McKeating

The paper shows hypoxia gene upregulation in chronic hepatitis B patients is not observed in in vitro or mouse models, suggesting inflammatory factors may drive this effect.

bioRxiv · Mar 27, 2020Microbiology

TCR and inflammatory signals tune human MAIT cells to exert specific tissue repair and effector functions

T. Leng, H. Delowar Akther, C.-P. Hackstein, T. King, M. Friedrich, Z. Christoforidou, S. McCuaig, M. Neyazi, C. V. Arancibia-Carcamo, F. Powrie, Oxford IBD Investigators, E. Marchi, R. Sanchesperes, V. Millar, D. Ebner, , P. Klenerman

This study investigates how TCR and inflammatory signals shape human MAIT cell functions, revealing their roles in tissue repair and effector responses.

bioRxiv · May 14, 2019Immunology

Activation and in vivo evolution of the MAIT cell transcriptome in mice and humans reveals diverse functionality

T. S. C. Hinks, E. Marchi, M. Jabeen, M. Olshansky, A. Kurioka, T. J. Pediongco, B. S. Meehan, L. Kostenko, S. J. Turner, A. J. Corbett, Z. Chen, P. Klenerman, J. McCluskey

The paper defines the transcriptome of activated MAIT cells in mice and humans and shows how it changes during infection phases, revealing a tissue repair phenotype.

bioRxiv · Dec 9, 2018 · PreprintImmunology

Type-2 CD8+ T lymphocytes responsive to PGD2 and LTE4 in severe eosinophilic asthma

B. Hilvering, T. S. Hinks, L. Stoger, E. Marchi, M. Salimi, R. Shrimanker, W. Liu, W. Chen, J. Luo, S. Go, T. Powell, J. Cane, S. Thulborn, A. Kurioka, T. Leng, , L. Xue

The paper identifies type-2 CD8+ T cells (Tc2) enriched in severe eosinophilic asthma and shows PGD2 and LTE4 drive their recruitment and activation, contributing to eosinophilia.

bioRxiv · Jan 12, 2018Immunology