Author

D. P. Fairlie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Organism:E. coli· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Organism:chicken / avian· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

J. Y. W. Mak· 3 shared P. Klenerman· 2 shared A. K. Kendall· 1 shared A. L. H. Kwa· 1 shared B. M. Collins· 1 shared B. Xie· 1 shared C. Boulouis· 1 shared C. vrettou· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersImmunology

J. Y. W. Mak

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Author profile →

4 papers

Recent·Most cited

MR1 dependent MAIT cell activation is regulated by autophagy associated proteins

P. Phalora, J. E. Ussher, S. Hester, E. Marchi, J. Y. W. Mak, D. P. Fairlie, P. Klenerman

The paper identifies SQSTM1/p62 as an MR1 interacting protein and shows its role in regulating MAIT cell activation through autophagy pathways.

bioRxiv · Sep 20, 2022 · PreprintCell Biology

De novo macrocyclic peptides for inhibiting, stabilising and probing the function of the Retromer endosomal trafficking complex

K.-E. Chen, Q. Guo, T. A. Hill, Y. Cui, A. K. Kendall, Z. Yang, R. J. Hall, M. Healy, J. Sacharz, S. J. Norwood, S. Fonseka, B. Xie, R. C. Reid, N. Leneva, R. G. Parton, , B. M. Collins

The paper develops macrocyclic peptides that inhibit, stabilize, and probe the Retromer complex's function, showing high affinity and specificity for different subunits.

bioRxiv · Dec 3, 2020 · PreprintBiochemistry

Identification and phenotype of MAIT cells in cattle and their response to bacterial infections

M. D. Edmans, T. K. Connelley, S. Jayaraman, C. vrettou, M. Vordermeier, J. Y. W. Mak, L. Liu, D. P. Fairlie, E. A. Maze, T. Chrun, P. Klenerman, S. B. G. Eckle, E. Tchilian, L. Benedictus

This study identifies and characterizes MAIT cells in cattle, showing their functional response to bacterial infections and their enrichment in mucosal tissues.

bioRxiv · Nov 9, 2020Immunology

Human MAIT cell cytolytic effector proteins synergize to overcome carbapenem resistance in Escherichia coli

C. Boulouis, W. R. Sia, M. Y. Gulam, J. Q. M. Teo, T. K. Phan, J. Y. W. Mak, D. P. Fairlie, I. K. H. Poon, T. H. Koh, P. Bergman, L.-F. Wang, A. L. H. Kwa, J. K. Sandberg, E. Leeansyah

This study shows human MAIT cells use granulysin and granzyme B to overcome carbapenem resistance in E. coli by increasing bacterial permeability and restoring carbapenem efficacy.

bioRxiv · Jan 16, 2020Immunology