Metabolic Reprogramming by Mutant GNAS Creates an Actionable Dependency in Intraductal Papillary Mucinous Neoplasms of the Pancreas
Y. Makino, K. I. Rajapakshe, B. C. Selvanesan, T. Okumura, K. Date, P. Dutta, L. Abou-Elkacem, A. Sagara, J. Min, M. Sans, N. Yee, M. J. Siemann, J. Enriquez, P. Smith, P. Bhattacharya, , F. I. Thege
This study shows that mutant GNAS drives a gastric metaplasia gene signature and glycolytic dependency in IPMNs, offering a therapeutic target.
Gut · Sep 13, 2024Peer-reviewedCancer Biology