Y. Makino

Metabolic Reprogramming by Mutant GNAS Creates an Actionable Dependency in Intraductal Papillary Mucinous Neoplasms of the Pancreas

This study shows that mutant GNAS drives a gastric metaplasia gene signature and glycolytic dependency in IPMNs, offering a therapeutic target.

Mutant GNAS drives a pyloric metaplasia with tumor suppressive glycans in intraductal papillary mucinous neoplasia

This study identifies GNASR201C as a driver of pyloric metaplasia in IPMN, characterized by tumor-suppressive glycans that inhibit cancer progression.

Integrated spatial transcriptomics and lipidomics of precursor lesions of pancreatic cancer identifies enrichment of long chain sulfatide biosynthesis as an early metabolic alteration

Spatial Transcriptomics of Intraductal Papillary Mucinous Neoplasms of The Pancreas Identifies NKX6-2 as a Driver of Gastric Differentiation and Indolent Biological Potential

This study identifies NKX6-2 as a driver of gastric differentiation in IPMNs, linking its expression to indolent biological potential and progression.

Engineering a highly durable adeno-associated virus receptor for analytical applications

The paper engineers a durable AAV receptor for analyzing AAV-AAVR interactions, showing diverse binding affinities among AAV serotypes and enabling quality checks and purification of AAV vectors.

PTEN-induced kinase 1 gene single-nucleotide variants as biomarkers in adjuvant chemotherapy for colorectal cancer

The paper identifies two single-nucleotide variants in the PTEN-induced kinase 1 gene associated with lower recurrence rates in colorectal cancer patients undergoing adjuvant chemotherapy.

Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project

This study integrates genomic and transcriptomic analysis of intraductal papillary mucinous neoplasms (IPMNs) to identify molecular features associated with progression to high-grade lesions and cancer.

Can SARS-CoV-2 transmit from a dead body?

This study investigates SARS-CoV-2 transmission from dead bodies using a hamster model, finding that transmission is possible but can be prevented by postmortem care and embalming.

Structural development of amyloid precursors in insulin B chain and the inhibition effect by fibrinogen

This study investigates the structural development of insulin B chain prefibrillar intermediates and how fibrinogen inhibits their fibril formation using multiple biophysical techniques.