Incorporation of 5 methylcytidine alleviates innate immune response to self-amplifying RNA vaccine
M. Komori, A. L. Morey, A. A. Quinones-Molina, J. Fofana, L. Romero, E. Peters, K. Matsuda, S. Gummuluru, J. F. Smith, W. Akahata, H. Akiyama
This study shows that incorporating 5-methylcytidine into saRNA vaccines reduces innate immune activation and adverse effects while maintaining strong immune responses.
bioRxiv · Nov 1, 2023 · PreprintImmunology