H. Yamamoto

Using variable data independent acquisition for capillary electrophoresis-based untargeted metabolomics

This study evaluates DIA techniques for CE-MS/MS metabolomics, showing vDIA with MS-DIAL improves annotation rates and accuracy, and identifies new metabolites in LPS-treated macrophages.

Microevolution toward loss of photosynthesis: Mutations promoting dark-heterotrophic growth and suppressing photosynthetic growth in cyanobacteria

The paper reports mutations in cyanobacteria that lead to loss of photosynthetic growth and promote dark-heterotrophic growth through a single gene mutation.

Extracellular vesicle-mediated secretion of chlorophyll biosynthetic intermediates in the cyanobacterium Leptolyngbya boryana

This study characterizes extracellular vesicles (EVs) from cyanobacteria, showing they contain chlorophyll intermediates and may help manage their accumulation.

A Tetravalent Dengue Virus-like Particle Vaccine Induces High levels of Neutralizing Antibodies and Inhibits Dengue Replication in Non-Human Primates

A tetravalent dengue VLP vaccine induces neutralizing antibodies and reduces viral replication in non-human primates without ADE.

Syntaxin 17 recruitment to mature autophagosomes is temporally regulated by PI4P accumulation

The paper shows that STX17 recruitment to mature autophagosomes is temporally regulated by PI4P-driven changes in membrane charge.

SIV-specific neutralizing antibody induction following selection of a PI3K drive-attenuated nef variant

This study shows that a PI3K drive-attenuated nef mutation in SIV leads to SIV-specific neutralizing antibody induction in infected macaques.

Comprehensive analysis of autophagic functions of WIPI family proteins and their implications for the pathogenesis of β-propeller associated neurodegeneration

This study investigates the roles of WIPI proteins in autophagy and their implications in β-propeller associated neurodegeneration, finding that WIPI2 is essential for autophagy and that some BPAN-related mutations affect autophagic activity.

A pulse-chasable reporter processing assay for mammalian autophagic flux with HaloTag

This paper introduces a HaloTag-based assay to monitor mammalian autophagic flux by detecting proteolytic processing of pulse-labeled reporters.

NCOA4 drives ferritin phase separation to facilitate macroferritinophagy and endosomal microferritinophagy

This study identifies NCOA4 as a driver of ferritin phase separation, enabling macroferritinophagy and endosomal microferritinophagy through multivalent interactions.

The dgc2 gene encoding di-guanylate cyclase suppresses both motility and biofilm formation in the filamentous cyanobacterium Leptolyngbya boryana.

This study identifies the dgc2 gene in Leptolyngbya boryana, showing that its inactivation suppresses motility and enhances biofilm formation, revealing a novel role for c-di-GMP in colony pattern formation.

Map7D2 and Map7D1 facilitate microtubule stabilization through distinct mechanisms in neuronal cells

This study identifies Map7D2 and Map7D1 as regulators of microtubule stability in neuronal cells, showing they function through distinct mechanisms.

Subacute SARS-CoV-2 replication can be controlled in the absence of CD8+ T cells in cynomolgus macaques

This study shows that subacute SARS-CoV-2 replication can be controlled without CD8+ T cells in cynomolgus macaques, suggesting CD8+ T-cell dysfunction may not solely cause viral control failure.

Evolution and insights into the structure and function of the DedA superfamily containing TMEM41B and VMP1

The paper identifies a new clade of bacterial proteins and reveals the evolutionary relationship and structural features of the DedA superfamily, including TMEM41B and VMP1.

Quantitative detection of sleep apnea with wearable watch device

This study uses PPG data from a wearable watch and the ACAT algorithm to detect sleep apnea, finding a strong correlation between CVHR frequency and AHI.

The expansion in lymphoid organs of IL-4+ BATF+ T follicular helper cells is linked to IgG4 class switching in vivo

The paper identifies IL-4+ BATF+ T follicular helper cells in IgG4-related disease that correlate with IgG4 class switching in lymphoid organs.