T. Nomura

CD34-positive monocytes are highly susceptible to HIV-1

This study identifies CD34+ monocytes as highly susceptible to HIV-1 infection, showing they harbor more proviral DNA and express higher HIV-1 receptors despite cART.

A Tetravalent Dengue Virus-like Particle Vaccine Induces High levels of Neutralizing Antibodies and Inhibits Dengue Replication in Non-Human Primates

A tetravalent dengue VLP vaccine induces neutralizing antibodies and reduces viral replication in non-human primates without ADE.

A Neanderthal/Denisovan GLI3 variant contributes to anatomical variations in mice

The paper investigates the effects of a Neanderthal/Denisovan GLI3 variant in mice, finding it alters skeletal morphology without affecting protein stability or activator-dependent transcription.

Identification of a Prunus MAX1 Homolog as a Unique Strigol Synthase from Carlactone Bypassing 5-Deoxystrigol

The paper identifies a Prunus MAX1 homolog as a strigol synthase that bypasses 5-deoxystrigol synthesis, directly converting carlactone to strigol.

Enterococcal linear plasmids adapt to Enterococcus faecium and spread within multidrug-resistant clades.

This study identifies enterococcal linear plasmids that spread AMR genes through horizontal transfer and contribute to multidrug resistance in Enterococcus faecium.

Mapping Protein Dynamics at High-Resolution with Temperature-Jump X-ray Crystallography

This study uses temperature-jump X-ray crystallography to observe atomic-scale protein motions in lysozyme, showing how vibrations evolve into functional movements and how inhibitors alter these dynamics.

Canonical Strigolactones Are Not the Tillering-Inhibitory Hormone but Rhizospheric Signals in Rice

This study shows canonical strigolactones in rice are not responsible for shoot branching inhibition but act as rhizospheric signals to influence Striga germination and mycorrhizal colonization.

An ancestral function of strigolactones as symbiotic rhizosphere signals

This study identifies BSB, an ancestral strigolactone in bryophytes, which functions as a rhizosphere signal for AM symbiosis and was later co-opted as a plant hormone.

Subacute SARS-CoV-2 replication can be controlled in the absence of CD8+ T cells in cynomolgus macaques

This study shows that subacute SARS-CoV-2 replication can be controlled without CD8+ T cells in cynomolgus macaques, suggesting CD8+ T-cell dysfunction may not solely cause viral control failure.

Hydroxyl carlactone derivatives are predominant strigolactones in Arabidopsis

The paper identifies hydroxyl carlactone derivatives as the main strigolactones in Arabidopsis, showing their biosynthesis via MAX1 and LBO enzymes.

Chemical identification of 18-hydroxycarlactonoic acid as an LjMAX1 product and conversion of 18-hydroxylcarlactonoates to canonical and non-canonical strigolactones in Lotus japonicus

This study identifies LjMAX1 as the key enzyme in Lotus japonicus strigolactone biosynthesis, showing it converts carlactone to 18-hydroxycarlactonoic acid, a precursor for both canonical and non-canonical strigolactones.

Comparing serial X-ray crystallography and microcrystal electron diffraction (MicroED) as methods for routine structure determination from small macromolecular crystals

This study compares serial X-ray crystallography and MicroED for determining structures from small macromolecular crystals, highlighting their strengths and challenges.

Overexpression of the vascular brassinosteroid receptor BRL3 confers drought resistance without penalizing plant growth

This study shows that overexpressing BRL3 in Arabidopsis improves drought tolerance without reducing growth.

Which are major players, canonical or non-canonical strigolactones?

The paper compares canonical and non-canonical strigolactones, showing non-canonical ones are major germination stimulants in root exudates and likely the true shoot branching inhibitors.