Pathogenicity, immunogenicity, and protective ability of an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction of the spike protein
P. Wang, S.-Y. Lau, S. Deng, P. Chen, B. W.-Y. Mok, A. J. Zhang, A. C.-Y. Lee, K.-H. Chan, W. Song, K. K.-W. To, J. F.-W. Chen, K.-Y. Yuen, H. Chen
This study characterizes an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction, showing reduced pathogenicity and immunogenicity but strong protective immunity.
bioRxiv · Aug 24, 2020 · PreprintMicrobiology