Author

A. J. Zhang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 5 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:trajectory inference· 1

Frequent Co-Authors

H. Chen· 4 shared K.-Y. Yuen· 4 shared S.-Y. Lau· 4 shared A. C.-Y. Lee· 3 shared B. W.-Y. Mok· 3 shared K. K.-W. To· 3 shared P. Wang· 3 shared S. Deng· 3 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersMicrobiology

H. Chen

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The SARS-CoV-2 Omicron (B.1.1.529) variant exhibits altered pathogenicity, transmissibility, and fitness in the golden Syrian hamster model

S. Yuan, Z.-W. Ye, R. Liang, K. Tang, A. J. Zhang, G. Lu, C. P. Ong, V. K.-M. Poon, C. C.-S. Chan, B. W. Y. Mok, Z. Qin, Y. Xie, H. Sun, J. O.-L. Tsang, T. T.-T. Yuen, , J. F. W. Chan

The study compares the pathogenicity, transmissibility, and fitness of SARS-CoV-2 Omicron and Delta variants in golden Syrian hamsters, finding Omicron less pathogenic but more transmissible and capable of outcompeting Delta under immune pressure.

bioRxiv · Jan 12, 2022 · PreprintMicrobiology

Nasal prevention of SARS-CoV-2 infection by intranasal influenza-based boost vaccination

R. Zhou, P. Wang, Y.-C. Wong, H. Xu, S.-Y. Lau, L. Liu, B. W.-Y. Mok, Q. Peng, N. Liu, S. Deng, R. C.-Y. Tam, H. Huang, A. J. Zhang, D. Zhou, B. Zhou, , Z. Chen

This study shows that intranasal influenza-based boost vaccination enhances mucosal and systemic immunity against SARS-CoV-2, effectively preventing infection in both upper and lower respiratory systems.

bioRxiv · Oct 21, 2021 · PreprintImmunology

Topoisomerase 1 inhibition therapy protects against SARS-CoV-2-induced inflammation and death in animal models.

J. S. Y. Ho, B. W.-Y. Mok, L. Campisi, T. Jordan, S. Yildiz, S. Parameswaran, J. A. Wayman, N. N. Gaudreault, D. A. Meekins, S. V. Indran, I. Morozov, J. D. Trujillo, Y. S. Fstkchyan, R. Rathnasinghe, Z. Zhu, , Jeya

This study shows that Top1 inhibition with Topotecan reduces SARS-CoV-2-induced inflammation and mortality in animal models.

bioRxiv · Dec 1, 2020 · PreprintMicrobiology

SARS-CoV-2 spike D614G variant exhibits highly efficient replication and transmission in hamsters

B. W. Y. Mok, C. J. Cremin, S.-Y. Lau, S. Deng, P. Chen, A. J. Zhang, A. C.-Y. Lee, H. Liu, S. Liu, T. T.-L. Ng, H.-Y. Lao, E. L.-K. Lee, K. S.-S. Leung, P. Wang, K. K.-W. To, , H. Chen

This study compares SARS-CoV-2 strains in hamsters, finding that the D614G spike variant shows higher replication and transmission efficiency.

bioRxiv · Aug 28, 2020 · PreprintMicrobiology

Pathogenicity, immunogenicity, and protective ability of an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction of the spike protein

P. Wang, S.-Y. Lau, S. Deng, P. Chen, B. W.-Y. Mok, A. J. Zhang, A. C.-Y. Lee, K.-H. Chan, W. Song, K. K.-W. To, J. F.-W. Chen, K.-Y. Yuen, H. Chen

This study characterizes an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction, showing reduced pathogenicity and immunogenicity but strong protective immunity.

bioRxiv · Aug 24, 2020 · PreprintMicrobiology