Author

K.-Y. Yuen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 14 Immunology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 18 Research Focus:host-pathogen & immune response· 17 Organism:human· 8 Organism:mouse· 8 Assay:proteomics· 5 Research Focus:cell type annotation· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2

Frequent Co-Authors

K. K.-W. To· 9 shared Z. Chen· 9 shared H. Chen· 7 shared J. F.-W. Chan· 7 shared L. Liu· 7 shared P. Wang· 7 shared S. Yuan· 7 shared D. D. Ho· 6 shared

Activity by Year

2018-2023 · peak 9/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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9 shared papersMicrobiology

K. K.-W. To

Mutual co-authors in cluster

Author profile →

19 papers

Recent·Most cited

Antibodies that neutralize all current SARS-CoV-2 variants of concern by conformational locking

L. Liu, R. G. Casner, Y. Guo, Q. Wang, S. Iketani, J. F.-W. Chan, J. Yu, B. Dadonaite, M. S. Nair, H. Mohri, E. R. Reddem, S. Yuan, V. K.-M. Poon, C. C.-S. Chan, K.-Y. Yuen, , D. D. Ho

This study identifies two antibodies that neutralize all SARS-CoV-2 variants by locking the spike protein in a down conformation, showing a novel mechanism and potential for prophylaxis.

bioRxiv · Apr 8, 2023 · PreprintMicrobiology

Three-dose vaccination-induced immune responses protect against SARS-CoV-2 Omicron-BA.2

R. Zhou, N. Liu, X. Li, Q. Peng, C.-K. Yiu, H. Huang, D. Yang, Z. Du, H.-Y. Kwok, K.-K. Au, J.-P. Cai, I. F.-N. Hung, K. K.-W. To, X. Xu, K.-Y. Yuen, Z. Chen

This study evaluates the effectiveness of three-dose SARS-CoV-2 vaccination against Omicron BA.2 breakthrough infections and finds that third-dose vaccination significantly reduces infection rates and severity.

bioRxiv · May 9, 2022 · PreprintImmunology

The SARS-CoV-2 Omicron (B.1.1.529) variant exhibits altered pathogenicity, transmissibility, and fitness in the golden Syrian hamster model

S. Yuan, Z.-W. Ye, R. Liang, K. Tang, A. J. Zhang, G. Lu, C. P. Ong, V. K.-M. Poon, C. C.-S. Chan, B. W. Y. Mok, Z. Qin, Y. Xie, H. Sun, J. O.-L. Tsang, T. T.-T. Yuen, , J. F. W. Chan

The study compares the pathogenicity, transmissibility, and fitness of SARS-CoV-2 Omicron and Delta variants in golden Syrian hamsters, finding Omicron less pathogenic but more transmissible and capable of outcompeting Delta under immune pressure.

bioRxiv · Jan 12, 2022 · PreprintMicrobiology

An elite broadly neutralizing antibody protects SARS-CoV-2 Omicron variant challenge

B. Zhou, R. Zhou, J. F.-W. Chan, M. Luo, Q. Peng, S. Yuan, B. W.-Y. Mok, B. Chen, P. Wang, V. K.-M. Poon, H. Chu, C. C.-S. Chan, J. O.-L. Tsang, C. C.-Y. Chan, K.-K. Au, , Z. Chen

This study identifies a broadly neutralizing antibody, ZCB11, effective against SARS-CoV-2 Omicron and Delta variants, showing protection in hamsters.

bioRxiv · Jan 5, 2022 · PreprintImmunology

Vaccine-breakthrough infection by the SARS-CoV-2 Omicron variant elicits broadly cross-reactive immune responses

R. Zhou, K. K.-W. To, Q. Peng, J. M.-C. Chan, H. Huang, D. Yang, B. H.-S. Lam, V. W.-M. Chuang, J.-P. Cai, N. Liu, K.-K. Au, O. T.-Y. Tsang, K.-Y. Yuen, Z. Chen

This study examines immune responses in vaccine-breakthrough Omicron infections, finding rapid cross-reactive neutralizing antibodies and T cell responses against multiple variants.

bioRxiv · Dec 27, 2021Immunology

Waning immune responses against SARS-CoV-2 among vaccinees in Hong Kong

Q. Peng, R. Zhou, Y. Wang, M. Zhao, N. Liu, S. Li, H. Huang, D. Yang, K.-K. Au, H. Wang, K. Man, K.-Y. Yuen, Z. Chen

This study compares immune responses between BioNTech and Sinovac vaccines in Hong Kong, finding Sinovac induces lower neutralizing antibodies and wanes faster against SARS-CoV-2 variants.

bioRxiv · Dec 22, 2021 · PreprintImmunology

Striking Antibody Evasion Manifested by the Omicron Variant of SARS-CoV-2

L. Liu, S. Iketani, Y. Guo, J. F.-W. Chan, M. Wang, L. Liu, Y. Luo, H. Chu, Y. Huang, M. S. Nair, J. Yu, K. K.-H. Chik, T. T.-T. Yuen, C. Yoon, K. K.-W. To, , D. D. Ho

This study shows that the Omicron variant of SARS-CoV-2 is highly resistant to neutralization by convalescent serum and vaccines, and many monoclonal antibodies.

bioRxiv · Dec 14, 2021Microbiology

Isolation and comparative analysis of antibodies that broadly neutralize sarbecoviruses

L. Liu, S. Iketani, Y. Guo, R. Casner, E. Reddem, M. S. Nair, J. Yu, J. Chan, M. Wang, G. Cerutti, Z. Li, C. Castagna, L. Corredor, H. Chu, S. Yuan, , D. D. Ho

The paper identifies a human monoclonal antibody that neutralizes all tested sarbecoviruses and describes a new antibody class with potential for pandemic preparedness.

bioRxiv · Dec 11, 2021 · PreprintMicrobiology

Nasal prevention of SARS-CoV-2 infection by intranasal influenza-based boost vaccination

R. Zhou, P. Wang, Y.-C. Wong, H. Xu, S.-Y. Lau, L. Liu, B. W.-Y. Mok, Q. Peng, N. Liu, S. Deng, R. C.-Y. Tam, H. Huang, A. J. Zhang, D. Zhou, B. Zhou, , Z. Chen

This study shows that intranasal influenza-based boost vaccination enhances mucosal and systemic immunity against SARS-CoV-2, effectively preventing infection in both upper and lower respiratory systems.

bioRxiv · Oct 21, 2021 · PreprintImmunology

A monoclonal antibody that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses

P. Wang, R. G. Casner, M. S. Nair, J. Yu, Y. Guo, M. Wang, J. F. W. Chan, G. Cerutti, S. Iketani, L. Liu, Z. Sheng, Z. Chen, K.-Y. Yuen, P. D. Kwong, Y. Huang, , D. D. Ho

This paper identifies a monoclonal antibody, 2-36, that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses, with a conserved epitope in the RBD identified through cryo-EM.

bioRxiv · Oct 13, 2021Microbiology

SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters

W. Qiao, H. E. Lau, H. Xie, V. K. M. Poon, C. C. S. Chan, H. Chu, S. Yuan, T. T. T. Yuen, K. K. H. Chik, J. O. L. Tsang, C. C. Y. Chan, J.-P. Cai, C. Luo, K.-Y. Yuen, K. M. C. Cheung, , K. W. K. Yeung

This study shows SARS-CoV-2 infection causes bone loss in golden Syrian hamsters through cytokine dysregulation and osteoclastogenesis.

bioRxiv · Oct 8, 2021Microbiology

SARS-CoV-2 hijacks neutralizing dimeric IgA for enhanced nasal infection and injury

B. Zhou, R. Zhou, J. F.-W. Chan, J. Zeng, Q. Zhang, S. Yuan, L. Liu, R. Robinot, S. Shan, J. Ge, H. Y.-H. Kwong, D. Zhou, H. Xu, C. C.-S. Chan, V. K.-M. Poon, , Z. Chen

This study shows that dimeric IgA antibodies can enhance SARS-CoV-2 nasal infection and injury in Syrian hamsters by engaging CD209 as an alternative receptor.

bioRxiv · Oct 5, 2021 · PreprintMicrobiology

Low dose inocula of SARS-CoV-2 B.1.1.7 variant initiate more robust infections in the upper respiratory tract of hamsters than earlier D614G variants

B. W.-Y. Mok, H. Liu, S.-Y. Lau, S. D. Deng, S. Liu, R. C.-Y. Tam, T. T.-L. Ng, J. S.-L. Leung, P. Wang, K. K.-W. To, J. F.-W. Chan, K.-H. Chan, K.-Y. Yuen, G. K.-H. Siu, H. Chen

This study shows that the B.1.1.7 SARS-CoV-2 variant replicates and sheds more efficiently in hamsters' nasal cavities than earlier D614G variants with lower doses and shorter exposure.

bioRxiv · Apr 19, 2021 · PreprintMicrobiology

SARS-CoV-2 spike D614G variant exhibits highly efficient replication and transmission in hamsters

B. W. Y. Mok, C. J. Cremin, S.-Y. Lau, S. Deng, P. Chen, A. J. Zhang, A. C.-Y. Lee, H. Liu, S. Liu, T. T.-L. Ng, H.-Y. Lao, E. L.-K. Lee, K. S.-S. Leung, P. Wang, K. K.-W. To, , H. Chen

This study compares SARS-CoV-2 strains in hamsters, finding that the D614G spike variant shows higher replication and transmission efficiency.

bioRxiv · Aug 28, 2020 · PreprintMicrobiology

Pathogenicity, immunogenicity, and protective ability of an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction of the spike protein

P. Wang, S.-Y. Lau, S. Deng, P. Chen, B. W.-Y. Mok, A. J. Zhang, A. C.-Y. Lee, K.-H. Chan, W. Song, K. K.-W. To, J. F.-W. Chen, K.-Y. Yuen, H. Chen

This study characterizes an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction, showing reduced pathogenicity and immunogenicity but strong protective immunity.

bioRxiv · Aug 24, 2020 · PreprintMicrobiology

Potent Neutralizing Antibodies Directed to Multiple Epitopes on SARS-CoV-2 Spike

L. Liu, P. Wang, M. S. Nair, J. Yu, M. Rapp, Q. Wang, Y. Luo, J. F.-W. Chan, V. Sahi, A. Figueroa, X. V. Guo, G. Cerutti, J. Bimela, J. Gorman, T. Zhou, , D. D. Ho

The paper isolates and characterizes 61 SARS-CoV-2-neutralizing monoclonal antibodies from infected patients, identifying potent antibodies targeting multiple epitopes on the spike protein.

Nature · Jul 22, 2020Peer-reviewedMicrobiology

Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes

S. Brouwer, T. C. Barnett, D. Ly, K. J. Kasper, D. M. De Oliveira, T. Rivera-Hernandez, A. J. Cork, L. McIntyre, M. G. Jespersen, J. Richter, B. L. Schulz, G. Dougan, V. Nizet, K.-Y. Yuen, Y. You, , M. J. Walker

This study identifies prophage-encoded exotoxins in Streptococcus pyogenes that enhance colonization fitness and pathogenesis in scarlet fever.

bioRxiv · May 17, 2020Microbiology

A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals

L. Riva, S. Yuan, X. Yin, L. Martin-Sancho, N. Matsunaga, S. Burgstaller, L. Pache, P. De Jesus, M. V. Hull, M. Chang, J. F. W. Chan, J. Cao, V. Kwok-Man Poon, K. Herbert, T.-T. Nguyen, , S. Chanda

This study identifies 30 known drugs that inhibit SARS-CoV-2 replication, with six showing effective concentrations likely to be therapeutic in patients.

bioRxiv · Apr 16, 2020 · PreprintMicrobiology

Replication of MERS and SARS coronaviruses in bat cells offers insights to their ancestral origins

S. Lau, R. Y. Fan, H. K. H. Luk, L. Zhu, J. Fung, K. S. Li, E. Y. M. Wong, S. S. Ahmed, J. F. W. Chan, K.-H. Kok, K.-H. Chan, U. Wernery, K.-y. Yuen, P. C. Y. Woo

This study replicates MERS and SARS coronaviruses in bat cells, finding that DPP4 expression and species-specific factors determine viral susceptibility.

bioRxiv · May 20, 2018Microbiology