Coupling between acid-sensing ion channel 1a and the monocarboxylate transporter family shapes cellular pH response
Mette Homann Poulsen, Nadine Ritter, S. Maurya, F. Xue, S. Haider, Samuel George Usher, Stephanie Andrea Heusser, Han Chow Chua, J. Fisker-Andersen, Stefanie Kickinger, Daniel Schramek, Petrine Wellendorph, Anne‐Kristine Lundby, Stephan Alexander Pless
The paper identifies a functional interaction between ASIC1a and MCT1 that modulates proton sensitivity and desensitization, showing its role in glioblastoma cell survival and mouse lifespan.
bioRxiv · Jun 30, 2025 · PreprintBiophysics