Author

Samuel George Usher

University of CopenhagenORCID 0000-0002-2487-6547Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Assay:electrophysiology· 1

Frequent Co-Authors

Stephan Alexander PlessiD· 3 shared Alexander LeitneriD· 1 shared Alexander S. HauseriD· 1 shared Anne‐Kristine Lundby· 1 shared Bernadette Lang· 1 shared Bettina Brokowski· 1 shared Changsi CaiiD· 1 shared Christian RosenmundiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersBiophysics

Stephan Alexander PlessORCID

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3 papers

Recent·Most cited

A deep learning-generated hASIC1a miniprotein inhibitor confers neuroprotection in stroke

Janina Sörmann, Konstantina Epitropaki, Maria Francesca Vicino, Christina Latt Fjorbak, Ciara Frances Pugh, Bernadette Lang, Emma Krindel Beyer, Raquel Comaposada Baro, Fabian Hink, Søren Friis, Samuel George Usher, Changsi Cai, Henriette Elisabeth Autzen, Joseph M. Rogers, Stephan Alexander Pless

This paper designs a deep learning-generated hASIC1a inhibitor that reduces infarct volume by over 50% in a mouse stroke model.

bioRxiv · Oct 9, 2026 · PreprintBiophysics

Coupling between acid-sensing ion channel 1a and the monocarboxylate transporter family shapes cellular pH response

Mette Homann Poulsen, Nadine Ritter, S. Maurya, F. Xue, S. Haider, Samuel George Usher, Stephanie Andrea Heusser, Han Chow Chua, J. Fisker-Andersen, Stefanie Kickinger, Daniel Schramek, Petrine Wellendorph, Anne‐Kristine Lundby, Stephan Alexander Pless

The paper identifies a functional interaction between ASIC1a and MCT1 that modulates proton sensitivity and desensitization, showing its role in glioblastoma cell survival and mouse lifespan.

bioRxiv · Jun 30, 2025 · PreprintBiophysics

The sodium leak channel NALCN is regulated by neuronal SNARE complex proteins

Samuel George Usher, Estelle Toulmé, Roberta Florea, Stanislau Yatskevich, Christine C. Jao, Luuk Robin Hoegen Dijkhof, Janne M. Colding, Prajakta Joshi, Inna Zilberleyb, Thorsten Trimbuch, Bettina Brokowski, Alexander S. Hauser, Alexander Leitner, Christian Rosenmund, Marc Kschonsak, Stephan Alexander Pless

The paper shows that SNARE complex proteins inhibit NALCN channel activity and that reducing NALCN currents promotes cell survival in syntaxin-depleted cells.

Science Advances · Mar 14, 2025Peer-reviewedNeuroscience