J. Grove

Mapping glycoprotein structure reveals defining events in the evolution of the Flaviviridae

The paper maps glycoprotein structures across Flaviviridae to identify evolutionary events shaping their virology and ecology.

A 39.8kb flavi-like virus uses a novel strategy for overcoming the RNA virus error threshold

This paper identifies a 39.8kb flavi-like virus without an exonuclease that overcomes the RNA virus error threshold by using bacterial nucleic acid metabolism domains.

Evidence of a novel viral membranefusion mechanism shared by theHepaci, Pegi and Pestiviruses

The paper predicts the structures of E1E2 glycoproteins from Hepaci, Pegi, and Pestivirus genera using AlphaFold, revealing a novel membrane fusion mechanism shared across these viruses.

Distantly related hepaciviruses share common entry factor, Claudin-1

This study identifies Claudin-1 as a shared entry factor for HCV and GBV-B, showing distinct mechanisms for each virus.

Litter commensal bacteria can limit the horizontal gene transfer of antimicrobial resistance to Salmonella in chickens

This study shows that commensal bacteria in reused chicken litter reduce horizontal gene transfer of antimicrobial resistance plasmids to Salmonella.

Characterisation of B.1.1.7 and Pangolin coronavirus spike provides insights on the evolutionary trajectory of SARS-CoV-2

This study characterizes the B.1.1.7 and Pangolin coronavirus spike proteins, revealing how NTD mutations enhance viral entry and provide insights into SARS-CoV-2 evolution.

Optimised cell systems for the investigation ofhepatitis C virus E1E2 glycoproteins

This paper identifies an optimized cell line for producing HCV pseudoparticles and reveals antigenic differences between sE2 produced in 293T and 293F cells.

Limited evolution despite years of measurable viremia in a cART-treated seronegative HIV-1 positive individual

The paper analyzes viral evolution in an HIV-1 infected individual on cART who lacked detectable antibodies, finding limited viral evolution despite prolonged viremia.

Building a mechanistic mathematical model of hepatitis C virus entry

The paper builds a mathematical model of HCV entry, showing sequential receptor interactions and estimating receptor requirements for viral entry.